MIR8079

Summary

MIR8079 (microRNA 8079, HGNC:50021) is a microRNA gene on chromosome 13q14.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465876 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50021
Approved symbol	MIR8079
Name	microRNA 8079
Location	13q14.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8079
Ensembl gene	ENSG00000276319
Ensembl biotype	miRNA
Entrez	102465876
RNAcentral	URS000075B5B4 — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610873

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610873 — 1 exons

Exon	Start	End
ENSE00003725770	44196129	44196200

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 73.80.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	73.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.43	gold quality
caudate nucleus	UBERON:0001873	63.91	gold quality
anterior cingulate cortex	UBERON:0009835	61.22	gold quality
skin of leg	UBERON:0001511	60.76	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Association between genetic polymorphisms of miRNAs (miR-8079 and miR-5007) and susceptibility of chronic obstructive pulmonary disease in Chinese people. (PMID:34455057)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.