MIR8081

Summary

MIR8081 (microRNA 8081, HGNC:50123) is a microRNA gene on chromosome 9q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465995 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50123
Approved symbol	MIR8081
Name	microRNA 8081
Location	9q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8081
Ensembl gene	ENSG00000277889
Ensembl biotype	miRNA
Entrez	102465995
RNAcentral	URS000075C4DC — ncRNA, 95 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611533

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611533 — 1 exons

Exon	Start	End
ENSE00003737121	106600928	106601022

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 67.60.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial artery	UBERON:0007610	67.60	gold quality
left lobe of thyroid gland	UBERON:0001120	67.26	gold quality
left ovary	UBERON:0002119	67.09	gold quality
body of stomach	UBERON:0001161	66.06	gold quality
heart left ventricle	UBERON:0002084	63.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.61	gold quality
omental fat pad	UBERON:0010414	63.42	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.01	gold quality
transverse colon	UBERON:0001157	60.75	gold quality
Ammon’s horn	UBERON:0001954	59.46	gold quality
colon	UBERON:0001155	58.91	gold quality
spleen	UBERON:0002106	58.80	gold quality
tibial nerve	UBERON:0001323	54.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.