MIR8082

Summary

MIR8082 (microRNA 8082, HGNC:50111) is a microRNA gene on chromosome 4q25.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465878 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50111
Approved symbol	MIR8082
Name	microRNA 8082
Location	4q25
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8082
Ensembl gene	ENSG00000275810
Ensembl biotype	miRNA
Entrez	102465878
RNAcentral	URS000075DCEA — ncRNA, 81 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612488

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612488 — 1 exons

Exon	Start	End
ENSE00003718991	113152282	113152362

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 85.14.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.14	gold quality
adrenal tissue	UBERON:0018303	81.77	gold quality
muscle of leg	UBERON:0001383	79.85	gold quality
prefrontal cortex	UBERON:0000451	73.58	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.48	gold quality
adult mammalian kidney	UBERON:0000082	72.12	gold quality
corpus callosum	UBERON:0002336	71.77	gold quality
gastrocnemius	UBERON:0001388	71.06	gold quality
heart	UBERON:0000948	70.68	gold quality
lung	UBERON:0002048	69.71	gold quality
heart left ventricle	UBERON:0002084	69.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.22	gold quality
endometrium	UBERON:0001295	69.04	gold quality
intestine	UBERON:0000160	68.94	gold quality
liver	UBERON:0002107	68.75	gold quality
prostate gland	UBERON:0002367	68.65	gold quality
anterior cingulate cortex	UBERON:0009835	68.64	gold quality
nucleus accumbens	UBERON:0001882	68.15	gold quality
tibial artery	UBERON:0007610	67.55	gold quality
amygdala	UBERON:0001876	67.26	gold quality
stomach	UBERON:0000945	67.22	gold quality
omental fat pad	UBERON:0010414	67.10	gold quality
substantia nigra	UBERON:0002038	66.85	gold quality
body of stomach	UBERON:0001161	66.83	gold quality
brain	UBERON:0000955	66.80	gold quality
thoracic mammary gland	UBERON:0005200	66.70	gold quality
colon	UBERON:0001155	66.68	gold quality
putamen	UBERON:0001874	66.64	gold quality
Ammon’s horn	UBERON:0001954	66.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in osteoarthritis. (PMID:36503346)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.