MIR8083

Summary

MIR8083 (microRNA 8083, HGNC:50211) is a microRNA gene on chromosome 1q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466879 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50211
Approved symbol	MIR8083
Name	microRNA 8083
Location	1q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8083
Ensembl gene	ENSG00000274940
Ensembl biotype	miRNA
Entrez	102466879
RNAcentral	URS000075CB0F — ncRNA, 89 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620823

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620823 — 1 exons

Exon	Start	End
ENSE00003725104	153689705	153689793

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 85.02.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ascending aorta	UBERON:0001496	85.02	gold quality
thoracic aorta	UBERON:0001515	84.79	gold quality
descending thoracic aorta	UBERON:0002345	84.24	gold quality
lower esophagus mucosa	UBERON:0035834	84.00	gold quality
skeletal muscle tissue	UBERON:0001134	82.51	gold quality
right uterine tube	UBERON:0001302	81.78	gold quality
subcutaneous adipose tissue	UBERON:0002190	79.96	gold quality
adipose tissue	UBERON:0001013	79.74	gold quality
vermiform appendix	UBERON:0001154	79.66	gold quality
omental fat pad	UBERON:0010414	79.44	gold quality
left coronary artery	UBERON:0001626	78.73	gold quality
mucosa of stomach	UBERON:0001199	78.67	gold quality
thoracic mammary gland	UBERON:0005200	76.78	gold quality
urinary bladder	UBERON:0001255	76.54	gold quality
adrenal tissue	UBERON:0018303	76.36	gold quality
kidney	UBERON:0002113	76.16	gold quality
upper lobe of left lung	UBERON:0008952	76.11	gold quality
lung	UBERON:0002048	76.04	gold quality
right ovary	UBERON:0002118	76.04	gold quality
adult mammalian kidney	UBERON:0000082	75.94	gold quality
popliteal artery	UBERON:0002250	75.63	gold quality
tibial artery	UBERON:0007610	75.61	gold quality
muscle of leg	UBERON:0001383	75.54	gold quality
gastrocnemius	UBERON:0001388	75.12	gold quality
right atrium auricular region	UBERON:0006631	75.10	gold quality
metanephros cortex	UBERON:0010533	74.99	gold quality
left ovary	UBERON:0002119	74.94	gold quality
ovary	UBERON:0000992	74.88	gold quality
heart	UBERON:0000948	74.79	gold quality
fundus of stomach	UBERON:0001160	74.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.