MIR8085

Summary

MIR8085 (microRNA 8085, HGNC:50120) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465879 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50120
Approved symbol	MIR8085
Name	microRNA 8085
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8085
Ensembl gene	ENSG00000284258
Ensembl biotype	miRNA
Entrez	102465879
RNAcentral	URS000075DB85 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612079

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612079 — 1 exons

Exon	Start	End
ENSE00003712480	44758657	44758721

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 74.22.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	74.22	gold quality
prefrontal cortex	UBERON:0000451	70.55	gold quality
caudate nucleus	UBERON:0001873	68.87	gold quality
gastrocnemius	UBERON:0001388	65.67	gold quality
amygdala	UBERON:0001876	65.56	gold quality
tibial artery	UBERON:0007610	63.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	57.41	gold quality
anterior cingulate cortex	UBERON:0009835	56.05	gold quality
ascending aorta	UBERON:0001496	54.63	gold quality
cerebellar hemisphere	UBERON:0002245	53.79	gold quality
body of pancreas	UBERON:0001150	53.02	gold quality
left ovary	UBERON:0002119	52.72	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.34	gold quality
tibial nerve	UBERON:0001323	49.83	gold quality
skin of leg	UBERON:0001511	36.01	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.