MIR8086

Summary

MIR8086 (microRNA 8086, HGNC:50107) is a microRNA gene on chromosome 10p12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465880 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50107
Approved symbol	MIR8086
Name	microRNA 8086
Location	10p12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8086
Ensembl gene	ENSG00000275036
Ensembl biotype	miRNA
Entrez	102465880
RNAcentral	URS0000759987 — ncRNA, 93 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621498

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621498 — 1 exons

Exon	Start	End
ENSE00003741272	28289258	28289350

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 76.79.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	76.79	gold quality
calcaneal tendon	UBERON:0003701	74.56	gold quality
sural nerve	UBERON:0015488	74.54	silver quality
blood	UBERON:0000178	74.45	gold quality
monocyte	CL:0000576	74.36	gold quality
gastrocnemius	UBERON:0001388	72.81	gold quality
islet of Langerhans	UBERON:0000006	72.07	gold quality
bone marrow	UBERON:0002371	72.04	gold quality
endometrium	UBERON:0001295	69.94	gold quality
adult mammalian kidney	UBERON:0000082	69.43	gold quality
stomach	UBERON:0000945	68.93	gold quality
prefrontal cortex	UBERON:0000451	68.84	gold quality
adrenal tissue	UBERON:0018303	67.54	gold quality
tibial artery	UBERON:0007610	67.08	gold quality
right lobe of thyroid gland	UBERON:0001119	66.01	gold quality
body of stomach	UBERON:0001161	66.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.76	gold quality
ascending aorta	UBERON:0001496	65.68	gold quality
thoracic aorta	UBERON:0001515	65.60	gold quality
liver	UBERON:0002107	65.42	gold quality
body of pancreas	UBERON:0001150	65.26	gold quality
right lung	UBERON:0002167	64.65	gold quality
thoracic mammary gland	UBERON:0005200	64.52	gold quality
putamen	UBERON:0001874	64.51	gold quality
left coronary artery	UBERON:0001626	64.27	gold quality
right adrenal gland cortex	UBERON:0035827	63.50	gold quality
right adrenal gland	UBERON:0001233	63.12	gold quality
body of uterus	UBERON:0009853	63.10	gold quality
esophagus mucosa	UBERON:0002469	62.92	gold quality
left adrenal gland	UBERON:0001234	62.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.