MIR8089

Summary

MIR8089 (microRNA 8089, HGNC:50196) is a microRNA gene on chromosome 5q35.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465882 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50196
Approved symbol	MIR8089
Name	microRNA 8089
Location	5q35.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-8089
Ensembl gene	ENSG00000277912
Ensembl biotype	miRNA
Entrez	102465882
RNAcentral	URS000075C3DD — ncRNA, 82 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620165

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620165 — 1 exons

Exon	Start	End
ENSE00003735623	181043403	181043484

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 84.90.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.90	gold quality
right lobe of liver	UBERON:0001114	75.51	gold quality
muscle of leg	UBERON:0001383	75.33	gold quality
gastrocnemius	UBERON:0001388	74.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.64	gold quality
apex of heart	UBERON:0002098	73.26	gold quality
adipose tissue	UBERON:0001013	73.13	gold quality
omental fat pad	UBERON:0010414	72.48	gold quality
left coronary artery	UBERON:0001626	71.99	gold quality
thoracic mammary gland	UBERON:0005200	71.96	gold quality
heart left ventricle	UBERON:0002084	71.68	gold quality
corpus callosum	UBERON:0002336	71.49	gold quality
heart	UBERON:0000948	71.45	gold quality
endometrium	UBERON:0001295	71.33	gold quality
right atrium auricular region	UBERON:0006631	71.04	gold quality
blood	UBERON:0000178	70.42	gold quality
monocyte	CL:0000576	70.36	gold quality
ovary	UBERON:0000992	68.54	gold quality
smooth muscle tissue	UBERON:0001135	68.43	gold quality
multicellular organism	UBERON:0000468	67.92	gold quality
left ovary	UBERON:0002119	67.90	gold quality
liver	UBERON:0002107	67.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.47	gold quality
body of pancreas	UBERON:0001150	67.24	gold quality
tibial artery	UBERON:0007610	67.07	gold quality
ascending aorta	UBERON:0001496	66.92	gold quality
fallopian tube	UBERON:0003889	66.63	gold quality
substantia nigra	UBERON:0002038	66.59	gold quality
body of stomach	UBERON:0001161	66.35	gold quality
right lung	UBERON:0002167	66.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.