MIR8485

Summary

MIR8485 (microRNA 8485, HGNC:50839) is a microRNA gene on chromosome 2p16.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 103504737 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50839
Approved symbol	MIR8485
Name	microRNA 8485
Location	2p16.3
Locus type	RNA, micro
Status	Approved
Ensembl gene	ENSG00000216191
Ensembl biotype	miRNA
Entrez	103504737
RNAcentral	URS000079BE2A — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401372

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401372 — 1 exons

Exon	Start	End
ENSE00001546716	50696172	50696262

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 92.74.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left lobe of thyroid gland	UBERON:0001120	92.74	gold quality
transverse colon	UBERON:0001157	90.02	gold quality
intestine	UBERON:0000160	85.72	gold quality
endometrium	UBERON:0001295	82.75	gold quality
calcaneal tendon	UBERON:0003701	79.42	gold quality
stomach	UBERON:0000945	78.83	gold quality
body of stomach	UBERON:0001161	77.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.30	gold quality
skin of abdomen	UBERON:0001416	76.02	gold quality
blood	UBERON:0000178	74.52	gold quality
body of pancreas	UBERON:0001150	73.30	gold quality
gastrocnemius	UBERON:0001388	72.80	gold quality
skin of leg	UBERON:0001511	72.37	gold quality
nucleus accumbens	UBERON:0001882	70.50	gold quality
heart left ventricle	UBERON:0002084	70.02	gold quality
right atrium auricular region	UBERON:0006631	69.96	gold quality
left adrenal gland	UBERON:0001234	69.52	gold quality
kidney	UBERON:0002113	68.88	gold quality
lung	UBERON:0002048	68.65	gold quality
hypothalamus	UBERON:0001898	68.16	gold quality
lymph node	UBERON:0000029	67.95	gold quality
anterior cingulate cortex	UBERON:0009835	66.42	gold quality
spleen	UBERON:0002106	66.29	gold quality
thyroid gland	UBERON:0002046	66.12	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.98	gold quality
caudate nucleus	UBERON:0001873	65.76	gold quality
right frontal lobe	UBERON:0002810	65.03	gold quality
omental fat pad	UBERON:0010414	64.55	gold quality
tibial artery	UBERON:0007610	64.29	gold quality
putamen	UBERON:0001874	64.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-NID1 represses NRXN1 expression by binding to TDP-43. (PMID:23827811)
• miR8485 was identified to be ectopically expressed. The exosomal miR8485 was capable of promoting the proliferation, migration and invasion of oral tumors. Study highlights the significance of mesenchymal stem cellsderived exosomes and exosomal miR8485 in premalignant lesions and carcinogenesis. (PMID:30896790)
• Chondrocytes-derived exosomal miR-8485 regulated the Wnt/beta-catenin pathways to promote chondrogenic differentiation of BMSCs. (PMID:31898972)
• miR-8485 alleviates the injury of cardiomyocytes through TP53INP1. (PMID:35876212)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.