MIR874

Summary

MIR874 (microRNA 874, HGNC:33643) is a microRNA gene on chromosome 5q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126343 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33643
Approved symbol	MIR874
Name	microRNA 874
Location	5q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-874
Ensembl gene	ENSG00000216009
Ensembl biotype	miRNA
OMIM	619450
Entrez	100126343
RNAcentral	URS000036AFF1 — miRNA, 78 nt, 26 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401190

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401190 — 1 exons

Exon	Start	End
ENSE00001546534	137647572	137647649

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 86.99.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	86.99	gold quality
blood	UBERON:0000178	79.68	gold quality
lung	UBERON:0002048	77.15	gold quality
calcaneal tendon	UBERON:0003701	75.65	gold quality
adrenal tissue	UBERON:0018303	75.44	gold quality
kidney	UBERON:0002113	74.47	gold quality
monocyte	CL:0000576	72.51	gold quality
gastrocnemius	UBERON:0001388	71.93	gold quality
body of stomach	UBERON:0001161	70.54	gold quality
heart	UBERON:0000948	70.47	gold quality
adult mammalian kidney	UBERON:0000082	70.41	gold quality
body of pancreas	UBERON:0001150	70.17	gold quality
right atrium auricular region	UBERON:0006631	69.82	gold quality
endometrium	UBERON:0001295	69.39	gold quality
stomach	UBERON:0000945	69.15	gold quality
heart left ventricle	UBERON:0002084	69.09	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.84	gold quality
ascending aorta	UBERON:0001496	68.28	gold quality
left coronary artery	UBERON:0001626	67.66	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.50	gold quality
tibial artery	UBERON:0007610	67.24	gold quality
intestine	UBERON:0000160	66.77	gold quality
right adrenal gland	UBERON:0001233	66.60	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.53	gold quality
left adrenal gland cortex	UBERON:0035825	66.30	gold quality
colon	UBERON:0001155	65.86	gold quality
amygdala	UBERON:0001876	65.85	gold quality
transverse colon	UBERON:0001157	65.82	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.77	gold quality
omental fat pad	UBERON:0010414	65.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Downregulation of miR-874 was a frequent event in HNSCC. miR-874 acted as a tumour suppressor and directly targeted HDAC1. (PMID:23558898)
• study highlights the possible tumor suppressor role of miR-874 in NSCLC-initiating cells and suggests miR-874 as a potential target in the treatment of NSCLC. (PMID:23583374)
• results provide a mechanism by which AQP3 is upregulated, as well as highlight the importance of miR-874 in gastric cancer development and progression. (PMID:23800944)
• MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9 (PMID:25281924)
• Findings indicate that down-regulation of miR-874 contributes to tumor angiogenesis through STAT3 in gastric cancer. (PMID:25596740)
• miR-874 functions as a tumor suppressor by repression of STAT3 in human colorectal cancer cells (PMID:26875895)
• our data suggested that miR-874-3p plays a tumour suppressive role in HCC through down-regulation of PIN1. (PMID:28076852)
• study found miR-874 expression was downregulated in 47 pairs of breast cancer tissues; miR-874, which might be served as a prognostic biomarker, is mediated by DNA methylation (PMID:28525377)
• our findings clarify a novel mechanism by which miR-874-3p restores chemotherapeutic sensitivity of colorectal cancer (CRC) to 5-FU, indicating that offering miR-874-3p mimics in combination with 5-FU may serve as a new therapeutic strategy to circumvent the chemoresistance in CRC (PMID:29039607)
• miR-874 inhibits CCNE1 expression during growth factor deprivation and that miR-874 down-regulation in osteosarcomas leads to CCNE1 up-regulation and more aggressive growth phenotypes. (PMID:29109143)
• miRNA-874 is a negative regulator of the DOR that can suppress tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway. (PMID:29374140)
• The findings of this study demonstrated that miR-874 inhibits TNF-alpha-induced remodeling in human fetal airway smooth muscle cells at least in part by targeting STAT3. (PMID:29448029)
• results of this study indicate that SIK2 expression can serve as a prognostic biomarker for EOC and that miR-874-3p and miR-874-5p have the potential to enhance clinical treatment of EOC (PMID:30004169)
• H19 acted as AQP1 ceRNA in regulating miR-874. (PMID:30021355)
• Study suggest that miR-874 is a novel miRNA, which regulates multidrug resistance (MDR) in gastric cancer cells. miR-874 inhibits autophagy by targeting ATG16L1 in MDR cells, leading to increased chemotherapeutic sensitivity. (PMID:30320370)
• The findings indicate miR-874 as a contributory role in cardiac ischemia-reperfusion injury…by targeting STAT3 through the JAK2/STAT3 signaling pathway. (PMID:30370578)
• STAT3 was a direct and functional target of miR-874-3p in esophageal squamous cell carcinoma cells, regulating cell proliferation and migration. (PMID:30468470)
• MiR-874-3p suppresses cell proliferation and invasion by targeting ADAM19 in nasopharyngeal carcinoma. (PMID:31352763)
• Long non-coding RNA FER1L4 promotes osteogenic differentiation of human periodontal ligament stromal cells via miR-874-3p and vascular endothelial growth factor A. (PMID:31900200)
• Reduced serum exosomal miR-874 expression predicts poor prognosis in colorectal cancer. (PMID:32016967)
• miR-874 directly targets AQP3 to inhibit cell proliferation, mobility and EMT in non-small cell lung cancer. (PMID:32301290)
• miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma. (PMID:32386256)
• MiR-874 Inhibits Cell Proliferation, Migration, and Invasion of Glioma Cells and Correlates with Prognosis of Glioma Patients. (PMID:32803522)
• GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells. (PMID:32851429)
• LncRNA MCF2L-AS1 aggravates proliferation, invasion and glycolysis of colorectal cancer cells via the crosstalk with miR-874-3p/FOXM1 signaling axis. (PMID:32860508)
• MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3. (PMID:32908641)
• Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression. (PMID:33025624)
• Long non-coding RNA MCF2L-AS1 promotes the aggressiveness of colorectal cancer by sponging miR-874-3p and thereby up-regulating CCNE1. (PMID:33037865)
• LncRNA DANCR upregulation induced by TUFT1 promotes malignant progression in triple negative breast cancer via miR-874-3p-SOX2 axis. (PMID:33058834)
• Ectopic expression of microRNA-874 represses epithelial mesenchymal transition through the NF-kappaB pathway via CCNE1 in cholangiocarcinoma. (PMID:33476715)
• MiR-874-3p plays a protective role in intervertebral disc degeneration by suppressing MMP2 and MMP3. (PMID:33482178)
• Long noncoding RNA DANCR confers cytarabine resistance in acute myeloid leukemia by activating autophagy via the miR-874-3P/ATG16L1 axis. (PMID:33638615)
• Circular RNA circANAPC2 mediates the impairment of endochondral ossification by miR-874-3p/SMAD3 signalling pathway in idiopathic short stature. (PMID:33713570)
• The direct miR-874-3p-target FAM84A promotes tumor development in papillary thyroid cancer. (PMID:33751775)
• Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells. (PMID:33797091)
• miR-874-3p mitigates cisplatin resistance through modulating NF-kappaB/inhibitor of apoptosis protein signaling pathway in epithelial ovarian cancer cells. (PMID:34716858)
• circ_0001588 Induces the Malignant Progression of Hepatocellular Carcinoma by Modulating miR-874/CDK4 Signaling. (PMID:34722778)
• MicroRNA miR-874-3p inhibits osteoporosis by targeting leptin (LEP). (PMID:34818977)
• Hsa_circ_0081534 facilitates malignant phenotypes by sequestering miR-874-3p and upregulating FMNL3 in nasopharyngeal carcinoma. (PMID:35428519)
• Upregulation of hsa_circ_0000977 participates in esophageal squamous cancer progression by sponging miR-874-3p. (PMID:35476874)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir874	ENSMUSG00000077962
rattus_norvegicus	Mir874	ENSRNOG00000041300

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.