MIR875

Summary

MIR875 (microRNA 875, HGNC:33652) is a microRNA gene on chromosome 8q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126309 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33652
Approved symbol	MIR875
Name	microRNA 875
Location	8q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-875
Ensembl gene	ENSG00000216069
Ensembl biotype	miRNA
Entrez	100126309
RNAcentral	URS000065D4D7 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401250

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401250 — 1 exons

Exon	Start	End
ENSE00001546594	99536786	99536861

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 85.30.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.30	gold quality
stomach	UBERON:0000945	80.09	gold quality
monocyte	CL:0000576	79.83	gold quality
blood	UBERON:0000178	79.03	gold quality
heart	UBERON:0000948	78.76	gold quality
adrenal tissue	UBERON:0018303	77.28	gold quality
liver	UBERON:0002107	74.79	gold quality
lung	UBERON:0002048	73.73	gold quality
gastrocnemius	UBERON:0001388	73.47	gold quality
endometrium	UBERON:0001295	72.71	gold quality
anterior cingulate cortex	UBERON:0009835	70.41	gold quality
endocervix	UBERON:0000458	70.07	gold quality
intestine	UBERON:0000160	69.71	gold quality
vagina	UBERON:0000996	67.97	gold quality
right atrium auricular region	UBERON:0006631	67.49	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.34	gold quality
right adrenal gland	UBERON:0001233	66.12	gold quality
right adrenal gland cortex	UBERON:0035827	66.10	gold quality
hypothalamus	UBERON:0001898	65.72	gold quality
body of pancreas	UBERON:0001150	65.64	gold quality
right frontal lobe	UBERON:0002810	65.29	gold quality
transverse colon	UBERON:0001157	65.11	gold quality
thoracic mammary gland	UBERON:0005200	64.93	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.87	gold quality
ascending aorta	UBERON:0001496	64.79	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.66	gold quality
colon	UBERON:0001155	64.28	gold quality
ectocervix	UBERON:0012249	64.21	gold quality
upper lobe of left lung	UBERON:0008952	64.19	gold quality
omental fat pad	UBERON:0010414	63.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Data show that the site targeted by two microRNAs, miR-875 and miR-3144 is located in HPV16 E6 oncogene open reading frame (ORF). (PMID:25913515)
• miR-875-5p played a pivotal role in colorectal carcinoma through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic EGFR (PMID:27302926)
• miR-875-5p reconstitution in prostate cancer cells counteracted epithelial-to-mesenchymal transition (EMT) and impaired DNA lesion clearance. (PMID:28274892)
• MiR-875-5pdirectly binds to the 3’untranslated region of SATB2. (PMID:29196257)
• MiR-875 can regulate the proliferation and apoptosis of non-small cell lung cancer cells via targeting SOCS2. (PMID:31298374)
• MiRNA-875-3p alleviates the progression of colorectal cancer via negatively regulating PLK1 level. (PMID:32096168)
• MicroRNA8755p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a. (PMID:33000235)
• NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway. (PMID:33452458)
• Long noncoding RNA HCG11 suppresses the malignant phenotype of nonsmall cell lung cancer cells by targeting a miR875/SATB2 axis. (PMID:34080031)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.