MIR876

Summary

MIR876 (microRNA 876, HGNC:33653) is a microRNA gene on chromosome 9p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126310 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33653
Approved symbol	MIR876
Name	microRNA 876
Location	9p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-876
Ensembl gene	ENSG00000215966
Ensembl biotype	miRNA
Entrez	100126310
RNAcentral	URS000006DA05 — miRNA, 81 nt, 46 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401147

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401147 — 1 exons

Exon	Start	End
ENSE00001546491	28863626	28863706

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 85.15.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.15	gold quality
blood	UBERON:0000178	84.33	gold quality
intestine	UBERON:0000160	77.98	gold quality
adrenal tissue	UBERON:0018303	75.02	gold quality
lung	UBERON:0002048	73.99	gold quality
endometrium	UBERON:0001295	73.20	gold quality
body of stomach	UBERON:0001161	73.03	gold quality
stomach	UBERON:0000945	71.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.64	gold quality
hypothalamus	UBERON:0001898	66.54	gold quality
transverse colon	UBERON:0001157	66.33	gold quality
esophagus mucosa	UBERON:0002469	64.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.60	gold quality
tibial nerve	UBERON:0001323	63.41	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.28	gold quality
left ovary	UBERON:0002119	63.20	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.12	gold quality
left adrenal gland cortex	UBERON:0035825	62.66	gold quality
thoracic mammary gland	UBERON:0005200	62.38	gold quality
anterior cingulate cortex	UBERON:0009835	62.08	gold quality
cerebellar hemisphere	UBERON:0002245	60.91	gold quality
right frontal lobe	UBERON:0002810	60.30	gold quality
spleen	UBERON:0002106	59.52	gold quality
left lobe of thyroid gland	UBERON:0001120	58.88	gold quality
myometrium	UBERON:0001296	57.73	gold quality
corpus callosum	UBERON:0002336	57.30	gold quality
right testis	UBERON:0004534	45.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 29)

• Data indicate a 9.5-fold upregulated microRNA miR-876-5p expression was observed in patients with severe enterovirus 71 (EV71) symptoms. (PMID:27052555)
• MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating BMP-4. (PMID:29229885)
• Study data reveal the strong biomarker potential of miR 876-3p for predicting the development of severe bronchopulmonary dysplasia in extremely premature infants, in addition to providing insight on the molecular mechanisms involved in the disease pathology as modulated by hyperoxia and microbial product-induced changes in exosomal miRNA 876-3p. (PMID:29515035)
• miR-876-5p was able to significantly decrease the expression level of choline kinase alpha mRNA. (PMID:29568919)
• Results show that miR-876-5p inhibits cell proliferation, migration and invasion of esophageal squamous cell carcinoma (ESCC) cells in vitro and suggest that miR-876-5p has tumor suppressive roles in ESCC cells. (PMID:29635069)
• MicroRNA-876-5p inhibits epithelial-mesenchymal transition progression, migration and invasion of hepatocellular carcinoma cells by targeting BCORL1. (PMID:29679906)
• that miR-876-5p suppressed hepatocellular carcinoma progression by targeting DNMT3A (PMID:29724530)
• miR-876-5p suppressed proliferation by restraining the expression of Ang-1, which would regulate the phosphorylation level of PI3K, AKT, mTOR and ERK in psoriasic cells. (PMID:29864894)
• critical determinant of adiponectin expression and regulates glucose homeostasis (PMID:30307150)
• c-Met restoration rescued miR-876-5p attenuated the proliferation, migration and invasion of osteosarcoma cells. (PMID:30773847)
• rescue assay uncovered a fact that miR-876-5p suppressed gastric cancer (GC) cell viability and migration, but induced cell apoptosis via targeting WNT5A and MITF. Taken together, we might offer a valuable evidence for miR-876-5p role in GC development. (PMID:31171711)
• PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression. (PMID:31700026)
• MicroRNA-876-5p represses the cell proliferation and invasion of colorectal cancer through suppressing YAP signalling via targeting RASAL2. (PMID:31990059)
• MicroRNA 876-5p modulates EV-A71 replication through downregulation of host antiviral factors. (PMID:32024541)
• Long noncoding RNA PITPNA-AS1 promotes cervical cancer progression through regulating the cell cycle and apoptosis by targeting the miR-876-5p/c-MET axis. (PMID:32460193)
• BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5. (PMID:32860757)
• miR-876 Inhibits EMT and Liver Fibrosis via POSTN to Suppress Metastasis in Hepatocellular Carcinoma. (PMID:33083453)
• CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression. (PMID:33232736)
• CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis. (PMID:33619796)
• The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway. (PMID:33683013)
• Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12. (PMID:34461926)
• miR-876-3p suppresses the progression of colon cancer and correlates the prognosis of patients. (PMID:34509500)
• Circ_0016760 Serves as a Cancer Promoter in Non-small Cell Lung Cancer Through miR-876-3p/NOVA2 Axis. (PMID:35239092)
• Circ_0062558 promotes growth, migration, and glutamine metabolism in triple-negative breast cancer by targeting the miR-876-3p/SLC1A5 axis. (PMID:35284960)
• lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5. (PMID:35412954)
• The HOXC-AS2/miR-876-5p/HKDC1 axis regulates endometrial cancer progression in a high glucose-related tumor microenvironment. (PMID:35485648)
• Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR-876-3p. (PMID:35856314)
• CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis. (PMID:36094501)
• miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK. (PMID:39138582)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir876	ENSMUSG00000077851

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.