MIR877

Summary

MIR877 (microRNA 877, HGNC:33660) is a microRNA gene on chromosome 6p21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126314 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33660
Approved symbol	MIR877
Name	microRNA 877
Location	6p21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-877
Ensembl gene	ENSG00000216101
Ensembl biotype	miRNA
OMIM	611619
Entrez	100126314
RNAcentral	URS00006A5378 — miRNA, 86 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401282

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401282 — 1 exons

Exon	Start	End
ENSE00001546626	30584332	30584417

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 93.17.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.17	gold quality
bone marrow	UBERON:0002371	85.35	gold quality
vermiform appendix	UBERON:0001154	79.58	gold quality
placenta	UBERON:0001987	76.79	gold quality
islet of Langerhans	UBERON:0000006	76.05	gold quality
lymph node	UBERON:0000029	74.57	gold quality
muscle of leg	UBERON:0001383	74.11	gold quality
liver	UBERON:0002107	73.75	gold quality
granulocyte	CL:0000094	73.71	gold quality
gastrocnemius	UBERON:0001388	73.32	gold quality
blood	UBERON:0000178	73.09	gold quality
prefrontal cortex	UBERON:0000451	72.65	gold quality
heart left ventricle	UBERON:0002084	71.52	gold quality
right lobe of liver	UBERON:0001114	71.22	gold quality
amygdala	UBERON:0001876	70.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.05	gold quality
stomach	UBERON:0000945	69.93	gold quality
body of stomach	UBERON:0001161	69.91	gold quality
endometrium	UBERON:0001295	69.72	gold quality
right atrium auricular region	UBERON:0006631	69.66	gold quality
adrenal gland	UBERON:0002369	69.39	gold quality
left adrenal gland	UBERON:0001234	68.99	gold quality
body of pancreas	UBERON:0001150	68.89	gold quality
left adrenal gland cortex	UBERON:0035825	68.55	gold quality
rectum	UBERON:0001052	68.25	gold quality
myometrium	UBERON:0001296	67.90	gold quality
minor salivary gland	UBERON:0001830	67.67	gold quality
right frontal lobe	UBERON:0002810	67.50	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.07	gold quality
transverse colon	UBERON:0001157	67.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 30)

• These results indicate that miR-877 could influence the sensitivity of paclitaxel treatment in hepatocellular carcinoma cell lines by targeting FOXM1. (PMID:25973036)
• The correlation between p16 activation and miR-877-3p was due to the direct binding. This demonstrates the anti-tumor function of miR-877-3p in bladder cancer cells and reveals a new pattern of miRNA involved gene regulation. (PMID:27429046)
• over-production of IL-8 induced by the secretory IgA was regulated by down-expression of miR-100-3p in mesangial cells. Similarly, IL-1beta over-production was regulated by down-expression of miR-877-3p. (PMID:27542871)
• TRG-AS1 promotes glioblastoma cell proliferation by acting as a ceRNA of miR-877-5p to regulate SUZ12 expression (PMID:31196742)
• Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis. (PMID:31737900)
• Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis. (PMID:31811909)
• LncRNA HOXA-AS2 accelerates the proliferation and migration and inhibits the apoptosis of vascular smooth muscle cells by absorbing miRNA-877-3p. (PMID:31957850)
• A genetic variant in the promoter region of miR-877 is associated with an increased risk of hepatocellular carcinoma. (PMID:32113822)
• MiR-877 suppresses gastric cancer progression by downregulating AQP3. (PMID:32543927)
• miR-877-5p antagonizes the promoting effect of SP on the gastric cancer progression. (PMID:32853022)
• HOXD-AS1 facilitates cell migration and invasion as an oncogenic lncRNA by competitively binding to miR-877-3p and upregulating FGF2 in human cervical cancer. (PMID:32977766)
• Long noncoding RNA DNAH17-AS1 promotes tumorigenesis and metastasis of non-small cell lung cancer via regulating miR-877-5p/CCNA2 pathway. (PMID:32981678)
• microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity. (PMID:33222607)
• MiR-877 suppresses tumor metastasis via regulating FOXM1 in ovarian cancer. (PMID:33721456)
• MicroRNA-877-5p alleviates ARDS via enhancing PI3K/Akt path by targeting CDKN1B both in vivo and in vitro. (PMID:33735715)
• miR-877 inhibits the proliferation, migration, and invasion of osteosarcoma cells by targeting gamma-glutamylcyclotransferase. (PMID:34121038)
• Hsa_circ_0042823 accelerates cancer progression via miR-877-5p/FOXM1 axis in laryngeal squamous cell carcinoma. (PMID:34124974)
• Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression. (PMID:34254950)
• miRNA-877-5p inhibits malignant progression of prostate cancer by directly targeting SSFA2. (PMID:34538046)
• microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1. (PMID:34654353)
• miR-877-3p inhibits tumor growth and angiogenesis of osteosarcoma through fibroblast growth factor 2 signaling. (PMID:34738872)
• CircCOL5A1 inhibits proliferation, migration, invasion, and extracellular matrix production of keloid fibroblasts by regulating the miR-877-5p/EGR1 axis. (PMID:35184918)
• Integration of bioinformatics analysis and experimental validation identifies plasma exosomal miR-103b/877-5p/29c-5p as diagnostic biomarkers for early lung adenocarcinoma. (PMID:35585716)
• MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer. (PMID:35756697)
• miR-877-5p Inhibits Epithelial Mesenchymal Transformation of Breast Cancer Cells by Targeting FGB. (PMID:36438895)
• miR-877-3p as a Potential Tumour Suppressor of Oesophageal Squamous Cell Carcinoma. (PMID:36585184)
• LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis. (PMID:36801505)
• Hsa-miR-877-5p Expression in Acute Ischemic Stroke Based on Bioinformatics Analysis and Clinical Validation. (PMID:37837492)
• MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression. (PMID:38342889)
• Signal Transducer and Activator of Transcription 4-Induced Up-Regulated LINC01278 Enhances Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via the MicroRNA-877-5p/Activating Transcription Factor 4 Axis. (PMID:38466361)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir877	ENSMUSG00000077931
rattus_norvegicus	Mir877	ENSRNOG00000041223

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.