MIR885

Summary

MIR885 (microRNA 885, HGNC:33659) is a microRNA gene on chromosome 3p25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126334 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33659
Approved symbol	MIR885
Name	microRNA 885
Location	3p25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-885
Ensembl gene	ENSG00000216135
Ensembl biotype	miRNA
Entrez	100126334
RNAcentral	URS0000726DE7 — miRNA, 74 nt, 31 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401316

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401316 — 1 exons

Exon	Start	End
ENSE00001546660	10394489	10394562

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 76.57.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	76.57	gold quality
substantia nigra	UBERON:0002038	71.40	gold quality
right lobe of liver	UBERON:0001114	69.86	gold quality
tibial nerve	UBERON:0001323	67.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.11	gold quality
right frontal lobe	UBERON:0002810	65.78	gold quality
putamen	UBERON:0001874	65.68	gold quality
ascending aorta	UBERON:0001496	65.39	gold quality
skin of leg	UBERON:0001511	65.13	gold quality
amygdala	UBERON:0001876	65.13	gold quality
gastrocnemius	UBERON:0001388	64.89	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.64	gold quality
body of pancreas	UBERON:0001150	62.48	gold quality
anterior cingulate cortex	UBERON:0009835	62.26	gold quality
cerebellar hemisphere	UBERON:0002245	62.08	gold quality
nucleus accumbens	UBERON:0001882	62.03	gold quality
hypothalamus	UBERON:0001898	61.65	gold quality
caudate nucleus	UBERON:0001873	61.00	gold quality
Ammon’s horn	UBERON:0001954	60.90	gold quality
pituitary gland	UBERON:0000007	57.19	gold quality
spleen	UBERON:0002106	56.85	gold quality
colon	UBERON:0001155	46.65	gold quality
testis	UBERON:0000473	44.08	gold quality
left testis	UBERON:0004533	41.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. (PMID:21233845)
• Results suggest that DSPP is regulated post-transcriptionally by mir32, mir885-5p and mir586 during odontoblast differentiation. (PMID:21687927)
• miR-885-3p has a role in the regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. (PMID:22071691)
• miR-885-5p binding site rs1049253T>C SNP in the 3’-UTR of CASP3 modulates CASP3 expression at both mRNA and protein levels and thus contributes to squamous cell carcinoma of the head and neck susceptibility. (PMID:23271051)
• mirn885-5p was associated with severe osteoarthritis requiring arthroplasty. (PMID:24515954)
• Results support a novel role for miR-885-3p in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor. (PMID:24882581)
• Findings suggest the involvement of hsa-miR-885-5p during Intrahepatic cholangiocarcinoma tumour progression and differentiation. and differentiation. (PMID:25017828)
• High serum miR-885-5p expression independently predicted prognosis, liver and distant metastasis, whereas tissue miR-885-5p expression did not. (PMID:25663689)
• During acute HCV infection, increases in miR-122 (P < 0.01) and miR-885-5p (Pcorrected < 0.05) and a decrease in miR-494 (Pcorrected < 0.05) were observed at the earliest time points after virus detection. (PMID:26157120)
• Mechanistic investigations indicated that DNp73 acted by attenuating expression of miR-885-5p, a direct regulator of the IGF1 receptor (IGF1R) responsible for stemness marker expression. (PMID:26554827)
• miR-885-5p is increased in plasma from Pre-eclampsia compared with healthy pregnant women, and it is released into circulation mainly inside exosomes. (PMID:26853698)
• The present study indicates that miR-885-5p suppresses the metastasis of HCC and inhibits Wnt/beta-catenin signaling pathway by its CTNNB1 target, which suggests that miR-885-5p to be a promising negative regulator of HCC progression and as a novel therapeutic agent to treat HCC. (PMID:27738331)
• Together hsa-miR-122-5p and -885-5p slightly improved the detection of fatty liver (FL) beyond established risk factors. These miRNAs may be associated with FL formation through the regulation of lipoprotein metabolism as hsa-miR-122-5p levels associated with small VLDL, IDL, and large LDL lipoprotein subclass components (PMID:27917915)
• Our findings demonstrated the overexpression of miR-885-5p in liver metastasis and its roles in inducing CRC metastasis, potentiating development of miR-885-5p inhibitor to treat advanced CRC in the future. (PMID:28460469)
• These results indicate that the noncoding RNAs MALAT1 and miR-885 show increased expression in neoplastic follicular and Hurthle cell thyroid neoplasms compared to normal thyroid tissues (PMID:28660408)
• The results confirmed the negative regulatory relationship between miR-885-3p and VDR. VDR is a virtual target of miR-885-3p, and Rs739837 polymorphism in MiR-885-3p binding site within 3’-untranslated region of vitamin D receptor is associated with a decreased risk of pressure ulcers. (PMID:29241179)
• These results demonstrate a novel regulatory axis of malignant cell proliferation and invasion in gastric cancer, comprising GCRL1, miR-885-3p, and CDK4. (PMID:29789536)
• Authors found that miR-885-5p was a direct target of hsa_circ_0004458, and silencing of hsa_circ_0004458 inhibited PTC cell proliferation by miR-885-5p. Authors also demonstrated that RAC1 was a direct target of miR-885-5p and silencing of RAC1 suppressed PTC cell proliferation. (PMID:30086127)
• Study revealed that Aurora A expression was significantly higher in docetaxelresistant lung adenocarcinoma (LAD) cells than in parental cells. miR8853p could target Aurora A directly acting as a chemosensitizer to docetaxel in human LAD cells. (PMID:30431113)
• Study results demonstrated that miR-885 promoted metastasis of colorectal cancer (CRC) in vitro, and that von Willebrand factor (vWF) and IGFBP5 are potential novel target genes of miR-885, indicating that the miR-885/vWF and miR-885/IGFBP5 axes may serve roles in the metastasis of CRC. (PMID:30542696)
• The miR-885-5p and its precursor both can interact mechanically with TIGAR promoter binding site and alter local chromatin structure, and subsequently upregulate TIGAR expression and participate in liver tumorigenesis. (PMID:31119791)
• MiR-885-5p promotes gastric cancer proliferation and invasion through regulating YPEL1. (PMID:31599416)
• miR-508-3p and miR-885-5p were found to be significantly dysregulated in ccRCC tissues and the serum of ccRCC patients. (PMID:31661117)
• MiR-885-3p is down-regulated in peripheral blood mononuclear cells from T1D patients and regulates the inflammatory response via targeting TLR4/NF-kappaB signaling. (PMID:31763742)
• miR-885 mediated cardioprotection against hypoxia/reoxygenation-induced apoptosis in human cardiomyocytes via inhibition of PTEN and BCL2L11 and modulation of AKT/mTOR signaling. (PMID:31960416)
• Plasma microRNA levels in male and female children with cystic fibrosis. (PMID:31980676)
• Rs739837 affects the severity of asthma by disrupting the binding of microRNA-885. (PMID:32157950)
• MicroRNA-885 regulates the growth and epithelial mesenchymal transition of human liver cancer cells by suppressing tropomodulin 1 expression. (PMID:32937160)
• Serum miR-885-5p can be used as a marker for efficacy prediction and prognosis of advanced liver cancer. (PMID:33040799)
• miR-885-5p inhibits proliferation and metastasis by targeting IGF2BP1 and GALNT3 in human intrahepatic cholangiocarcinoma. (PMID:33052627)
• miR-885-5p Inhibits Invasion and Metastasis in Gastric Cancer by Targeting Malic Enzyme 1. (PMID:33751897)
• The ATO/miRNA-885-5p/MTPN axis induces reversal of drug-resistance in cholangiocarcinoma. (PMID:34170484)
• Identification of miR-885-5p as a Tumor Biomarker: Regulation of Cellular Function in Cervical Cancer. (PMID:34801999)
• CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults. (PMID:35045349)
• MicroRNA-885-3p alleviates bronchial epithelial cell injury induced by lipopolysaccharide via toll-like receptor 4. (PMID:35156897)
• Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway. (PMID:35383130)
• Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19. (PMID:35772782)
• Downregulation of miR-885-5p Promotes NF-kappaB Pathway Activation and Immune Recruitment in Cutaneous Lupus Erythematosus. (PMID:36049539)
• Long Noncoding RNA HOXA-AS2 Facilitates Prostate Cancer Progression by Inhibiting miR-885-5p to Upregulate KDM5B. (PMID:36404720)
• m[6]A methylation-mediated regulation of LncRNA MEG3 suppresses ovarian cancer progression through miR-885-5p and the VASH1 pathway. (PMID:38281945)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.