MIR887

Summary

MIR887 (microRNA 887, HGNC:33661) is a microRNA gene on chromosome 5p15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126347 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33661
Approved symbol	MIR887
Name	microRNA 887
Location	5p15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-887
Ensembl gene	ENSG00000216077
Ensembl biotype	miRNA
OMIM	620117
Entrez	100126347
RNAcentral	URS000062DC91 — miRNA, 79 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401258

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401258 — 1 exons

Exon	Start	End
ENSE00001546602	15935182	15935260

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 80.89.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	80.89	gold quality
vermiform appendix	UBERON:0001154	80.63	gold quality
adrenal tissue	UBERON:0018303	80.12	gold quality
smooth muscle tissue	UBERON:0001135	77.47	gold quality
right uterine tube	UBERON:0001302	76.66	gold quality
right ovary	UBERON:0002118	75.47	gold quality
kidney	UBERON:0002113	74.40	gold quality
muscle of leg	UBERON:0001383	73.55	gold quality
ovary	UBERON:0000992	73.44	gold quality
left ovary	UBERON:0002119	73.21	gold quality
gastrocnemius	UBERON:0001388	73.20	gold quality
monocyte	CL:0000576	73.02	gold quality
calcaneal tendon	UBERON:0003701	72.96	gold quality
blood	UBERON:0000178	72.86	gold quality
left adrenal gland cortex	UBERON:0035825	72.64	gold quality
myometrium	UBERON:0001296	72.45	gold quality
urinary bladder	UBERON:0001255	72.29	gold quality
tibial artery	UBERON:0007610	72.17	gold quality
islet of Langerhans	UBERON:0000006	72.13	gold quality
popliteal artery	UBERON:0002250	72.08	gold quality
endocervix	UBERON:0000458	72.05	gold quality
right adrenal gland	UBERON:0001233	71.38	gold quality
liver	UBERON:0002107	71.36	gold quality
adrenal gland	UBERON:0002369	71.32	gold quality
endometrium	UBERON:0001295	71.27	gold quality
body of uterus	UBERON:0009853	71.01	gold quality
heart left ventricle	UBERON:0002084	70.84	gold quality
stomach	UBERON:0000945	70.70	gold quality
fundus of stomach	UBERON:0001160	70.57	gold quality
left adrenal gland	UBERON:0001234	70.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• we show using reporter gene assays and endogenous MDM4 expression analyses that miR-191-5p and miR-887 have a specific affinity for the rs4245739 SNP C-allele in prostate cancer (PMID:25670033)
• Low aggressive MCF-7 breast cancer cells have low endogenous PLD enzymatic activity and cell invasion, concomitant with high expression of miR-203, -887, and -3619 and miR-182 and miR-182. (PMID:26567912)
• Serum miR-887-5p levels were significantly increased in patients with endometrial cancer. (PMID:27177284)
• Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function. (PMID:32321279)
• MicroRNA analysis of NCI-60 human cancer cells indicates that miR-720 and miR-887 are potential therapeutic biomarkers for breast cancer. (PMID:32863323)
• Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway. (PMID:35655918)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.