MIR888

Summary

MIR888 (microRNA 888, HGNC:33648) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126306 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33648
Approved symbol	MIR888
Name	microRNA 888
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-888
Ensembl gene	ENSG00000216005
Ensembl biotype	miRNA
Entrez	100126306
RNAcentral	URS000075C9F0 — miRNA, 77 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401186

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401186 — 1 exons

Exon	Start	End
ENSE00001546530	145994784	145994860

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 77.57.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epididymis	UBERON:0001301	77.57	gold quality
lung	UBERON:0002048	71.31	gold quality
body of stomach	UBERON:0001161	67.94	gold quality
skin of leg	UBERON:0001511	67.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.90	gold quality
transverse colon	UBERON:0001157	66.26	gold quality
right atrium auricular region	UBERON:0006631	64.26	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.77	gold quality
endocervix	UBERON:0000458	63.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.55	gold quality
right lobe of thyroid gland	UBERON:0001119	63.10	gold quality
caudate nucleus	UBERON:0001873	62.91	gold quality
tibial nerve	UBERON:0001323	62.64	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.30	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.19	gold quality
corpus callosum	UBERON:0002336	61.41	gold quality
left ovary	UBERON:0002119	60.54	gold quality
Ammon’s horn	UBERON:0001954	59.99	gold quality
spleen	UBERON:0002106	59.22	gold quality
frontal cortex	UBERON:0001870	58.89	gold quality
right frontal lobe	UBERON:0002810	57.38	gold quality
anterior cingulate cortex	UBERON:0009835	54.94	gold quality
hypothalamus	UBERON:0001898	39.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• miR-888 functions to promote prostate cancer progression and can suppress protein levels of the tumor suppressor genes RBL1 and SMAD4. (PMID:24200968)
• Over-expression of miR-888 reduced the mRNA levels of E-cadherin in MCF-7 side population sphere cells. (PMID:24480745)
• miR-888 maintains SP properties and regulates EMT and metastasis in MCF-7 cells, potentially by targeting E-Cadherin expression (PMID:24845571)
• miR-888-5p increased the expression of MMP-2 and MMP-9 proteins that promoted cell migration and invasion, and decreased the expression of p53 protein which further enhanced the cell tumorigenicity. (PMID:28337887)
• MiR-888 promotes cell migration and invasion of hepatocellular carcinoma by targeting SMAD4. (PMID:30915745)
• the immunohistochemical results and The Cancer Genome Atlas (TCGA) database revealed that CDC7 was significantly upregulated in lung adenocarcinoma tissues, suggesting that miR888 may function as an oncogene in the progression of lung adenocarcinoma patients, and the miR888/CDC7 axis was not the dominant pathway for CDC7 regulation in patients with lung adenocarcinoma (PMID:31002360)
• Study showed that upregulation of miR-888-3p was associated with idiopathic asthenozoospermia (AZS). This finding paves the way to the future investigation on the actual molecular role of miR-888-3p in aetiology of AZS. (PMID:31012127)
• Circ-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement. (PMID:35068326)
• miR-888 and E-Cadherin Levels in Ductal Carcinoma Breast Cancer as Possible Cancer-Related Markers. (PMID:35442769)
• CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. (PMID:36334805)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.