MIR889

Summary

MIR889 (microRNA 889, HGNC:33651) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126345 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33651
Approved symbol	MIR889
Name	microRNA 889
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-889
Ensembl gene	ENSG00000216099
Ensembl biotype	miRNA
Entrez	100126345
RNAcentral	URS000075D4A4 — miRNA, 79 nt, 15 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401280

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401280 — 1 exons

Exon	Start	End
ENSE00001546624	101047901	101047979

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 96.97.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.97	gold quality
kidney	UBERON:0002113	92.87	gold quality
endometrium	UBERON:0001295	81.75	gold quality
intestine	UBERON:0000160	80.33	gold quality
muscle of leg	UBERON:0001383	79.42	gold quality
stomach	UBERON:0000945	79.09	gold quality
heart	UBERON:0000948	78.41	gold quality
lung	UBERON:0002048	77.35	gold quality
monocyte	CL:0000576	73.47	gold quality
calcaneal tendon	UBERON:0003701	73.08	gold quality
left adrenal gland cortex	UBERON:0035825	71.95	gold quality
placenta	UBERON:0001987	71.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	71.34	gold quality
colon	UBERON:0001155	69.20	gold quality
left ovary	UBERON:0002119	68.98	gold quality
esophagus	UBERON:0001043	68.60	gold quality
left adrenal gland	UBERON:0001234	67.91	gold quality
right atrium auricular region	UBERON:0006631	67.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.12	gold quality
amygdala	UBERON:0001876	66.17	gold quality
fundus of stomach	UBERON:0001160	65.99	gold quality
ascending aorta	UBERON:0001496	65.51	gold quality
anterior cingulate cortex	UBERON:0009835	64.79	gold quality
body of stomach	UBERON:0001161	64.73	gold quality
body of pancreas	UBERON:0001150	64.65	gold quality
omental fat pad	UBERON:0010414	64.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.61	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.53	gold quality
caudate nucleus	UBERON:0001873	63.50	gold quality
left lobe of thyroid gland	UBERON:0001120	63.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• MicroRNA-889 promotes cell proliferation in colorectal cancer by targeting DAB2IP. (PMID:31081086)
• the present results indicated that miR889 inhibits the aggressive behaviors of nonsmall cell lung cancer (NSCLC) by directly targeting TAB1 mRNA, thus highlighting the importance of the miR889/TAB1 pathway in the malignant progression of NSCLC. (PMID:31115539)
• negative role in inducing osteogenic differentiation of bone marrow mesenchymal stem cells through Wnt beta-catenin signaling pathway (PMID:31727100)
• Long Noncoding RNA XIST Contributes to Cervical Cancer Development Through Targeting miR-889-3p/SIX1 Axis. (PMID:32191528)
• Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7. (PMID:33782039)
• Enhanced expression of miR-889 forecasts an unfavorable prognosis and facilitates cell progression in hepatocellular carcinoma. (PMID:34116691)
• MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1. (PMID:34723781)
• Tumour-suppressing functions of the lncRNA MBNL1-AS1/miR-889-3p/KLF9 axis in human breast cancer cells. (PMID:35112997)
• NNT-AS1 in CAFs-derived exosomes promotes progression and glucose metabolism through miR-889-3p/HIF-1alpha in pancreatic adenocarcinoma. (PMID:38521881)
• Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p. (PMID:38570856)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.