MIR890

Summary

MIR890 (microRNA 890, HGNC:33644) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126303 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33644
Approved symbol	MIR890
Name	microRNA 890
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-890
Ensembl gene	ENSG00000216075
Ensembl biotype	miRNA
Entrez	100126303
RNAcentral	URS000075A116 — miRNA, 77 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401256

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401256 — 1 exons

Exon	Start	End
ENSE00001546600	145994275	145994351

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 82.08.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.08	gold quality
adrenal tissue	UBERON:0018303	75.53	gold quality
gastrocnemius	UBERON:0001388	73.07	gold quality
substantia nigra	UBERON:0002038	68.87	gold quality
thoracic aorta	UBERON:0001515	67.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.70	gold quality
right atrium auricular region	UBERON:0006631	67.57	gold quality
epididymis	UBERON:0001301	65.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.03	gold quality
urinary bladder	UBERON:0001255	63.36	gold quality
transverse colon	UBERON:0001157	63.27	gold quality
tibial nerve	UBERON:0001323	63.22	gold quality
skin of abdomen	UBERON:0001416	62.88	gold quality
body of uterus	UBERON:0009853	62.72	gold quality
Ammon’s horn	UBERON:0001954	61.66	gold quality
prostate gland	UBERON:0002367	61.25	gold quality
right frontal lobe	UBERON:0002810	61.23	gold quality
endocervix	UBERON:0000458	60.56	gold quality
left ovary	UBERON:0002119	60.54	gold quality
corpus callosum	UBERON:0002336	54.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• this study shows that MiR-890 inhibits proliferation and invasion and induces apoptosis in triple-negative breast cancer cells by targeting CD147 (PMID:31196010)
• LINC00662 promotes cell proliferation, migration and invasion of melanoma by sponging miR-890 to upregulate ELK3. (PMID:32894549)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.