MIR891B

Summary

MIR891B (microRNA 891b, HGNC:33645) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126304 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33645
Approved symbol	MIR891B
Name	microRNA 891b
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-891b
Ensembl gene	ENSG00000216064
Ensembl biotype	miRNA
Entrez	100126304
RNAcentral	URS0000676F0F — miRNA, 79 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401245

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401245 — 1 exons

Exon	Start	End
ENSE00001809152	146001053	146001131

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 71.23.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	71.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.72	gold quality
body of pancreas	UBERON:0001150	69.02	gold quality
right atrium auricular region	UBERON:0006631	67.81	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.01	gold quality
urinary bladder	UBERON:0001255	66.56	gold quality
skin of abdomen	UBERON:0001416	64.96	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.07	gold quality
omental fat pad	UBERON:0010414	62.21	gold quality
minor salivary gland	UBERON:0001830	62.07	gold quality
tibial nerve	UBERON:0001323	59.76	gold quality
metanephros cortex	UBERON:0010533	59.22	gold quality
substantia nigra	UBERON:0002038	58.34	gold quality
skin of leg	UBERON:0001511	58.28	gold quality
right frontal lobe	UBERON:0002810	56.59	gold quality
thyroid gland	UBERON:0002046	55.66	gold quality
epididymis	UBERON:0001301	55.15	silver quality
corpus callosum	UBERON:0002336	48.60	silver quality
left testis	UBERON:0004533	42.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-891b regulated the Smad3/ p21 axis by directly targeting the Cbl-b gene to inhibit the proliferative ability of pancreatic adenocarcinoma cells. (PMID:27494897)
• Studied increased sensitivity to alkylating antineoplastic agents thru down-regulation of poly(ADP-ribose) polymerase 1 (PARP1) by miR-891b in a human breast cancer cell line. Found MiR-891b increases sensitivity of breast cancer cell line to N-methyl-N-nitro-N-nitrosoguanidine by suppressing PARP1 expression. (PMID:28660502)
• Host relieves lnc-IRAK3-3-sequestered miR-891b to attenuate apoptosis in Enterovirus 71 infection. (PMID:31099182)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.