MIR892A

Summary

MIR892A (microRNA 892a, HGNC:33639) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126342 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33639
Approved symbol	MIR892A
Name	microRNA 892a
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-892a
Ensembl gene	ENSG00000215943
Ensembl biotype	miRNA
Entrez	100126342
RNAcentral	URS0000759C52 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401124

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401124 — 1 exons

Exon	Start	End
ENSE00001546468	145996669	145996743

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 75.46.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	75.46	gold quality
gastrocnemius	UBERON:0001388	73.60	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.15	gold quality
heart left ventricle	UBERON:0002084	69.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.93	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.56	gold quality
body of stomach	UBERON:0001161	67.76	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.48	gold quality
Ammon’s horn	UBERON:0001954	67.47	gold quality
right lobe of liver	UBERON:0001114	67.38	gold quality
substantia nigra	UBERON:0002038	67.00	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.70	gold quality
amygdala	UBERON:0001876	66.69	gold quality
right atrium auricular region	UBERON:0006631	66.46	gold quality
ascending aorta	UBERON:0001496	66.32	gold quality
tibial artery	UBERON:0007610	66.13	gold quality
cerebral cortex	UBERON:0000956	65.90	gold quality
transverse colon	UBERON:0001157	65.60	gold quality
brain	UBERON:0000955	65.02	gold quality
caudate nucleus	UBERON:0001873	64.42	gold quality
putamen	UBERON:0001874	64.40	gold quality
esophagus mucosa	UBERON:0002469	64.40	gold quality
left ovary	UBERON:0002119	64.32	gold quality
skin of abdomen	UBERON:0001416	64.07	gold quality
right ovary	UBERON:0002118	63.74	gold quality
right frontal lobe	UBERON:0002810	63.58	gold quality
anterior cingulate cortex	UBERON:0009835	63.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.54	gold quality
body of uterus	UBERON:0009853	63.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR892a inhibited the expression of the CYP1A1 protein (PMID:22470100)
• Prognostic value of miR-892a in gastric cancer and its regulatory effect on tumor progression. (PMID:32390603)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.