MIR892B

Summary

MIR892B (microRNA 892b, HGNC:33649) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126307 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33649
Approved symbol	MIR892B
Name	microRNA 892b
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-892b
Ensembl gene	ENSG00000216098
Ensembl biotype	miRNA
Entrez	100126307
RNAcentral	URS0000759FDD — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401279

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401279 — 1 exons

Exon	Start	End
ENSE00001546623	145997198	145997274

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 76.91.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	76.91	gold quality
epididymis	UBERON:0001301	74.12	gold quality
heart left ventricle	UBERON:0002084	73.28	gold quality
right atrium auricular region	UBERON:0006631	70.81	gold quality
skin of abdomen	UBERON:0001416	69.92	gold quality
blood	UBERON:0000178	69.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.37	gold quality
substantia nigra	UBERON:0002038	68.29	gold quality
Ammon’s horn	UBERON:0001954	67.88	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.47	gold quality
right frontal lobe	UBERON:0002810	66.37	gold quality
frontal lobe	UBERON:0016525	66.36	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.26	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.21	gold quality
amygdala	UBERON:0001876	66.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.39	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.09	gold quality
brain	UBERON:0000955	65.00	gold quality
putamen	UBERON:0001874	64.86	gold quality
skin of leg	UBERON:0001511	64.05	gold quality
left coronary artery	UBERON:0001626	63.74	gold quality
omental fat pad	UBERON:0010414	63.59	gold quality
thoracic mammary gland	UBERON:0005200	63.54	gold quality
left ovary	UBERON:0002119	63.48	gold quality
hypothalamus	UBERON:0001898	62.81	gold quality
caudate nucleus	UBERON:0001873	62.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.56	gold quality
tibial nerve	UBERON:0001323	62.39	gold quality
anterior cingulate cortex	UBERON:0009835	62.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-892b silencing in breast cancer cells sustains NF-kappaB activity (PMID:26747895)
• Five miRNAs were significantly upregulated in type 2 diabetes mellitus patients (p < 0.05) including miR-661, miR-571, miR-770-5p, miR-892b and miR-1303. Moreover, the levels of the five miRNAs were higher in patients with complications than in those without complications. (PMID:26831044)
• we verified that miR-892b regulates the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers. (PMID:27573859)
• Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b. (PMID:30382592)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.