MIR892C

Summary

MIR892C (microRNA 892c, HGNC:50194) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466721 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50194
Approved symbol	MIR892C
Name	microRNA 892c
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-892c
Ensembl gene	ENSG00000252219
Ensembl biotype	miRNA
Entrez	102466721
RNAcentral	URS000075C34B — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516410

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516410 — 1 exons

Exon	Start	End
ENSE00002088687	145992750	145992826

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 75.36.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.36	gold quality
gastrocnemius	UBERON:0001388	73.21	gold quality
tibial artery	UBERON:0007610	70.55	gold quality
adult mammalian kidney	UBERON:0000082	70.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.52	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.54	gold quality
omental fat pad	UBERON:0010414	64.90	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.83	gold quality
skin of leg	UBERON:0001511	62.88	gold quality
esophagus mucosa	UBERON:0002469	62.82	gold quality
Ammon’s horn	UBERON:0001954	62.25	gold quality
caudate nucleus	UBERON:0001873	61.44	gold quality
right frontal lobe	UBERON:0002810	60.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.50	gold quality
tibial nerve	UBERON:0001323	57.35	gold quality
left testis	UBERON:0004533	43.97	gold quality
corpus callosum	UBERON:0002336	43.52	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.