MIR9-1HG

Summary

MIR9-1HG (MIR9-1 host gene, HGNC:30780) is a long non-coding RNA gene on chromosome 1q22. May play a role in FOS signaling pathways involved in development and remodeling of neurons.

Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 10485 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30780
Approved symbol	MIR9-1HG
Name	MIR9-1 host gene
Location	1q22
Locus type	RNA, long non-coding
Status	Approved
Aliases	CROC4
Ensembl gene	ENSG00000125462
Ensembl biotype	lncRNA
OMIM	618747
Entrez	10485
RNAcentral	URS0001BBE48E — lncRNA, 706 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 200 — 200 lncRNA

ENST00000310027, ENST00000357975, ENST00000368242, ENST00000368243, ENST00000400991, ENST00000441085, ENST00000452465, ENST00000462458, ENST00000463309, ENST00000464203, ENST00000464238, ENST00000465270, ENST00000465570, ENST00000469813, ENST00000471156, ENST00000476966, ENST00000482932, ENST00000484428, ENST00000486517, ENST00000488498, ENST00000489877, ENST00000489918, ENST00000492750, ENST00000495000, ENST00000497822, ENST00000497824, ENST00000498346, ENST00000608007, ENST00000656222, ENST00000663987, ENST00000667036, ENST00000673141, ENST00000700991, ENST00000701195, ENST00000701576, ENST00000701766, ENST00000701992, ENST00000702047, ENST00000702128, ENST00000702336, ENST00000702396, ENST00000702513, ENST00000702702, ENST00000702770, ENST00000702884, ENST00000702897, ENST00000702912, ENST00000702915, ENST00000702918, ENST00000702928, ENST00000702936, ENST00000702937, ENST00000702952, ENST00000702953, ENST00000702966, ENST00000702968, ENST00000702969, ENST00000702972, ENST00000702975, ENST00000702978, ENST00000702990, ENST00000702998, ENST00000702999, ENST00000703000, ENST00000703018, ENST00000703026, ENST00000703029, ENST00000703031, ENST00000703035, ENST00000703043, ENST00000703047, ENST00000703048, ENST00000703052, ENST00000703053, ENST00000703058, ENST00000703062, ENST00000703065, ENST00000703067, ENST00000703069, ENST00000703072, ENST00000703073, ENST00000703078, ENST00000703079, ENST00000703083, ENST00000703084, ENST00000703085, ENST00000703086, ENST00000703088, ENST00000703089, ENST00000703090, ENST00000703092, ENST00000703093, ENST00000703094, ENST00000703095, ENST00000703098, ENST00000758273, ENST00000758274, ENST00000758275, ENST00000758276, ENST00000758277, ENST00000758278, ENST00000758279, ENST00000758280, ENST00000758281, ENST00000758282, ENST00000758283, ENST00000758284, ENST00000758285, ENST00000758286, ENST00000758287, ENST00000758288, ENST00000758289, ENST00000758290, ENST00000758291, ENST00000758292, ENST00000758293, ENST00000758294, ENST00000758295, ENST00000758296, ENST00000758297, ENST00000758298, ENST00000758299, ENST00000758300, ENST00000758301, ENST00000758302, ENST00000758303, ENST00000758304, ENST00000758305, ENST00000758306, ENST00000758307, ENST00000758308, ENST00000758309, ENST00000758310, ENST00000758311, ENST00000758312, ENST00000758313, ENST00000758314, ENST00000758315, ENST00000758316, ENST00000758317, ENST00000758318, ENST00000758319, ENST00000758320, ENST00000758321, ENST00000758322, ENST00000758323, ENST00000758324, ENST00000758325, ENST00000758326, ENST00000758327, ENST00000758328, ENST00000758329, ENST00000758330, ENST00000758331, ENST00000758332, ENST00000758333, ENST00000758334, ENST00000758335, ENST00000758336, ENST00000758337, ENST00000758338, ENST00000758339, ENST00000758340, ENST00000758341, ENST00000758342, ENST00000758343, ENST00000758344, ENST00000758345, ENST00000758346, ENST00000758347, ENST00000758348, ENST00000758349, ENST00000758350, ENST00000758351, ENST00000758352, ENST00000758353, ENST00000758354, ENST00000758355, ENST00000758356, ENST00000758357, ENST00000758358, ENST00000758359, ENST00000758360, ENST00000758361, ENST00000758362, ENST00000758363, ENST00000758364, ENST00000758365, ENST00000758366, ENST00000758367, ENST00000758368, ENST00000758369, ENST00000758370, ENST00000758371, ENST00000792507, ENST00000792508, ENST00000792509, ENST00000792510, ENST00000792511, ENST00000792512

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000310027 — 5 exons

Exon	Start	End
ENSE00001946068	156404250	156404601
ENSE00003543775	156407842	156407975
ENSE00003598939	156414654	156414753
ENSE00003607413	156426798	156426872
ENSE00004110133	156429376	156429631

Expression profiles

Bgee: expression breadth ubiquitous, 208 present calls, max score 99.92.

FANTOM5 (CAGE): breadth broad, TPM avg 25.5070 / max 857.5192, expressed in 552 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
15120	14.8951	191
15118	9.3799	497
15111	0.2332	77
15121	0.2076	90
15114	0.1722	104
15116	0.1393	41
15117	0.1120	35
15112	0.0948	51
15107	0.0692	6
15113	0.0554	35

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	99.92	gold quality
ganglionic eminence	UBERON:0004023	99.80	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	99.70	gold quality
nucleus accumbens	UBERON:0001882	99.69	gold quality
right frontal lobe	UBERON:0002810	99.68	gold quality
paraflocculus	UBERON:0005351	99.65	gold quality
putamen	UBERON:0001874	99.63	gold quality
caudate nucleus	UBERON:0001873	99.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.53	gold quality
amygdala	UBERON:0001876	99.51	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	99.51	gold quality
hypothalamus	UBERON:0001898	99.50	gold quality
Brodmann (1909) area 9	UBERON:0013540	99.48	gold quality
inferior olivary complex	UBERON:0002127	99.44	gold quality
cerebellar hemisphere	UBERON:0002245	99.40	gold quality
Ammon’s horn	UBERON:0001954	99.39	gold quality
entorhinal cortex	UBERON:0002728	99.37	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	99.35	gold quality
temporal lobe	UBERON:0001871	99.32	gold quality
cerebellar cortex	UBERON:0002129	99.31	gold quality
substantia nigra	UBERON:0002038	99.29	gold quality
middle frontal gyrus	UBERON:0002702	99.28	gold quality
anterior cingulate cortex	UBERON:0009835	99.28	gold quality
telencephalon	UBERON:0001893	99.26	gold quality
cingulate cortex	UBERON:0003027	99.25	gold quality
cerebral cortex	UBERON:0000956	99.24	gold quality
cerebellum	UBERON:0002037	99.22	gold quality
neocortex	UBERON:0001950	99.14	gold quality
cortical plate	UBERON:0005343	99.14	gold quality
prefrontal cortex	UBERON:0000451	99.12	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	27.74
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
FOS	Activation

Literature-anchored findings (GeneRIF, showing 2)

• CACNA1G-AS1 promotes hepatocellular carcinoma progression through regulating the miR-2392/C1orf61 pathway. (PMID:30908634)
• C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib. (PMID:33915231)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.