MIR920

Summary

MIR920 (microRNA 920, HGNC:33670) is a microRNA gene on chromosome 12p12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126320 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33670
Approved symbol	MIR920
Name	microRNA 920
Location	12p12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-920
Ensembl gene	ENSG00000216192
Ensembl biotype	miRNA
Entrez	100126320
RNAcentral	URS000067E0B9 — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401373

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401373 — 1 exons

Exon	Start	End
ENSE00001546717	24212421	24212495

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 95.87.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	95.87	gold quality
muscle of leg	UBERON:0001383	88.60	gold quality
adult mammalian kidney	UBERON:0000082	83.97	gold quality
kidney	UBERON:0002113	82.21	gold quality
lung	UBERON:0002048	81.23	gold quality
adrenal tissue	UBERON:0018303	80.71	gold quality
monocyte	CL:0000576	79.05	gold quality
corpus callosum	UBERON:0002336	78.72	gold quality
endocervix	UBERON:0000458	77.70	gold quality
blood	UBERON:0000178	77.57	gold quality
liver	UBERON:0002107	77.32	gold quality
stomach	UBERON:0000945	75.98	gold quality
endometrium	UBERON:0001295	74.74	gold quality
gastrocnemius	UBERON:0001388	73.56	gold quality
heart	UBERON:0000948	73.34	gold quality
lymph node	UBERON:0000029	73.30	gold quality
Ammon’s horn	UBERON:0001954	71.78	gold quality
heart left ventricle	UBERON:0002084	71.68	gold quality
right lung	UBERON:0002167	71.46	gold quality
gall bladder	UBERON:0002110	70.99	gold quality
prefrontal cortex	UBERON:0000451	70.18	gold quality
right lobe of liver	UBERON:0001114	69.20	gold quality
intestine	UBERON:0000160	68.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.44	gold quality
colon	UBERON:0001155	68.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.17	gold quality
body of stomach	UBERON:0001161	68.16	gold quality
anterior cingulate cortex	UBERON:0009835	67.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.76	gold quality
body of pancreas	UBERON:0001150	67.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• genetic changes in betaTrCP may influence hepatocellular carcinoma (HCC) risk, likely through at least in part by hsa-miR-920-mediated regulation, which is possibly involved in the pathogenesis of HCC. (PMID:19931512)
• This study demonstrates the roles of miR-488 and miR-920 in regulating the production of proinflammatory cytokines in the pathogenesis of gouty arthritis (PMID:28915828)
• miR-625 and miR-920 are involved in the TGF-beta pathway; miR-625 but not miR920 is downregulated in patients with liver cirrhosis (PMID:30969085)
• MiR-920 promotes osteogenic differentiation of human bone mesenchymal stem cells by targeting HOXA7. (PMID:32650806)
• MiR-920 and LSP1 co-regulate the growth and migration of glioblastoma cells by modulation of JAK2/STAT5 pathway. (PMID:32770294)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.