MIR921

Summary

MIR921 (microRNA 921, HGNC:33671) is a microRNA gene on chromosome 1q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126349 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33671
Approved symbol	MIR921
Name	microRNA 921
Location	1q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-921
Ensembl gene	ENSG00000215952
Ensembl biotype	miRNA
Entrez	100126349
RNAcentral	URS000075C577 — miRNA, 56 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401133

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401133 — 1 exons

Exon	Start	End
ENSE00001546477	166154743	166154798

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 80.89.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.89	gold quality
muscle of leg	UBERON:0001383	77.57	gold quality
gastrocnemius	UBERON:0001388	77.49	gold quality
stomach	UBERON:0000945	77.36	gold quality
calcaneal tendon	UBERON:0003701	76.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.24	gold quality
heart	UBERON:0000948	75.37	gold quality
kidney	UBERON:0002113	74.49	gold quality
rectum	UBERON:0001052	74.14	gold quality
heart left ventricle	UBERON:0002084	73.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.97	gold quality
pituitary gland	UBERON:0000007	72.60	gold quality
minor salivary gland	UBERON:0001830	71.71	gold quality
right frontal lobe	UBERON:0002810	71.10	gold quality
adult mammalian kidney	UBERON:0000082	70.87	gold quality
body of stomach	UBERON:0001161	70.86	gold quality
body of pancreas	UBERON:0001150	70.78	gold quality
right lobe of liver	UBERON:0001114	70.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.37	gold quality
frontal cortex	UBERON:0001870	69.47	gold quality
intestine	UBERON:0000160	69.44	gold quality
transverse colon	UBERON:0001157	69.41	gold quality
anterior cingulate cortex	UBERON:0009835	68.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.41	gold quality
substantia nigra	UBERON:0002038	67.85	gold quality
left adrenal gland cortex	UBERON:0035825	67.80	gold quality
colon	UBERON:0001155	67.74	gold quality
thyroid gland	UBERON:0002046	67.70	gold quality
nucleus accumbens	UBERON:0001882	67.67	gold quality
cerebellar hemisphere	UBERON:0002245	67.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• regulation of human CBR1 expression by hsa-miR-574-5p and hsa-miR-921 depends upon rs9024 genotype status (PMID:23133646)
• Study found that miR-921 expression is downregulated in A549 lung cancer cells. Further data demonstrate that miR-921 directly inhibits GPx3 expression in A549 lung cancer cells. (PMID:30898707)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.