MIR922

Summary

MIR922 (microRNA 922, HGNC:33672) is a microRNA gene on chromosome 3q29.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126321 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33672
Approved symbol	MIR922
Name	microRNA 922
Location	3q29
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-922
Ensembl gene	ENSG00000284146
Ensembl biotype	miRNA
Entrez	100126321
RNAcentral	URS0000718B2A — miRNA, 81 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401223

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401223 — 1 exons

Exon	Start	End
ENSE00001546567	197674496	197674576

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 83.55.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	83.55	gold quality
adrenal gland	UBERON:0002369	79.20	gold quality
stomach	UBERON:0000945	77.38	gold quality
prostate gland	UBERON:0002367	72.33	gold quality
muscle of leg	UBERON:0001383	70.60	gold quality
vermiform appendix	UBERON:0001154	68.18	gold quality
multicellular organism	UBERON:0000468	67.96	gold quality
blood	UBERON:0000178	67.30	gold quality
ovary	UBERON:0000992	65.26	gold quality
colon	UBERON:0001155	64.61	gold quality
right lobe of thyroid gland	UBERON:0001119	60.03	gold quality
gastrocnemius	UBERON:0001388	58.10	gold quality
body of pancreas	UBERON:0001150	50.25	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	45.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Global miRNA profiling quantitatively confirms miR-922, miR-181c, and miR-633 are differentially regulated in patients with multiple sclerosis as compared with other diseases. (PMID:23077021)
• miR-922 increasing the levels of phosphorylated tau by regulating UCHL1 levels contributed to the pathogenesis of Alzheimer diseases. (PMID:24950120)
• High miR922 expression is associated with hepatocellular carcinoma. (PMID:28184924)
• miR-922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer. (PMID:31709719)
• CCHE1 accelerated the initiation of oral squamous cell carcinoma through enhancing PAK2 expression by sponging miR-922. (PMID:31981240)
• CREB1 acts via the miR922/ARID2 axis to enhance malignant behavior of liver cancer cells. (PMID:33786634)
• Value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia.", trans “miR-922miR-506. (PMID:34719417)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.