MIR924

Summary

MIR924 (microRNA 924, HGNC:33674) is a microRNA gene on chromosome 18q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126323 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33674
Approved symbol	MIR924
Name	microRNA 924
Location	18q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-924
Ensembl gene	ENSG00000283615
Ensembl biotype	miRNA
Entrez	100126323
RNAcentral	URS00006C1626 — miRNA, 53 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638017

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638017 — 1 exons

Exon	Start	End
ENSE00003796584	39622123	39622175

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 90.19.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	90.19	gold quality
heart	UBERON:0000948	82.65	gold quality
lung	UBERON:0002048	80.46	gold quality
intestine	UBERON:0000160	80.02	gold quality
stomach	UBERON:0000945	78.80	gold quality
liver	UBERON:0002107	76.63	gold quality
body of pancreas	UBERON:0001150	72.30	gold quality
colon	UBERON:0001155	71.64	gold quality
caudate nucleus	UBERON:0001873	70.90	gold quality
right lobe of liver	UBERON:0001114	70.77	gold quality
blood	UBERON:0000178	70.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.85	gold quality
omental fat pad	UBERON:0010414	66.06	gold quality
upper lobe of left lung	UBERON:0008952	65.79	gold quality
esophagus mucosa	UBERON:0002469	64.87	gold quality
skin of leg	UBERON:0001511	64.52	gold quality
spleen	UBERON:0002106	63.82	gold quality
vagina	UBERON:0000996	63.42	gold quality
skin of abdomen	UBERON:0001416	63.26	gold quality
endometrium	UBERON:0001295	62.57	gold quality
right testis	UBERON:0004534	57.68	gold quality
testis	UBERON:0000473	49.96	gold quality
left testis	UBERON:0004533	48.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Mechanistic studies showed lncRNA n335586 promoted hepatocellular carcinoma (HCC) cells migration and invasion through facilitating the expression of its host gene mitochondrial creatine kinase (CKMT1A) by competitively binding miR-924. (PMID:29753758)
• Circ_0000463 contributes to the progression and glutamine metabolism of non-small-cell lung cancer by targeting miR-924/SLC1A5 signaling. (PMID:34811815)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.