MIR92A1

Summary

MIR92A1 (microRNA 92a-1, HGNC:31643) is a microRNA gene on chromosome 13q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407048 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31643
Approved symbol	MIR92A1
Name	microRNA 92a-1
Location	13q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-92-1, hsa-mir-92a-1
Ensembl gene	ENSG00000283705
Ensembl biotype	miRNA
OMIM	609422
Entrez	407048
RNAcentral	URS00002B6637 — miRNA, 78 nt, 41 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385233

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385233 — 1 exons

Exon	Start	End
ENSE00002710490	91351314	91351391

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 76.21.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.21	gold quality
placenta	UBERON:0001987	71.69	gold quality
skin of abdomen	UBERON:0001416	58.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• a circuit involving c-myc, miR-17-92, and HIF-1 alpha may play a role in cancer cell proliferation under normoxia in a cellular context-dependent manner [miR-92] (PMID:18632605)
• Plasma miR-92a value could be a novel biomarker not only for diagnosis but also for monitoring lymphoma patients after chemotherapy. (PMID:21383985)
• Atheroprotective flow patterns decrease the level of miR-92a, which in turn increases KLF2 expression to maintain endothelial homeostasis. (PMID:21768538)
• data indicate that miR-92a plays a pivotal role in the development of colorectal carcinoma (PMID:21883694)
• the miR-17~92 cluster has a compact globular tertiary structure where miRNAs internalized within the core of the folded structure are processed less efficiently than miRNAs on the surface of the structure. (PMID:21955497)
• In ST-segment elevation myocardial infarction patients, the expression of circulating miR-92a is up-regulated. PCI therapy may suppress such up-regulation. (PMID:22153007)
• The miR-92a expression varied between tumours and was inversely correlated to tumour grade and recurrence-free survival and provided independent prognostic information in multivariate Cox analysis. (PMID:22563438)
• Increased circulating miR-92a is associated with malignant pleural mesothelioma. (PMID:22617246)
• findings demonstrate that the high expression of miR-92a in glioma is significantly correlated with low levels of BCL2L11 (Bim) protein and high-grade glioma (PMID:22895567)
• MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase (PMID:23355465)
• The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells. (PMID:23499550)
• levels of miR-21 and miR-92a in patients with colorectal cancer (CRC) and advanced adenoma were significantly higher than those in healthy controls; data indicate miR-21 and miR-92a serum levels have potential value for early detection of CRC; miR-92a has prognostic value in CRC patients (PMID:23625654)
• Data indicate that miR-17-92 families miR-19b, miR-20a, miR-25 and miR-92a might implicate in apoptosis induction in the some of the cells and conditions. (PMID:23681423)
• There were significant correlations between miR-92 serum expression and regional lymph node involvement and clinical stage of the tumor. (PMID:23963852)
• MicroRNA-92a might be a novel potential biomarker in the diagnosis of colorectal cancer. (PMID:24551148)
• MicroRNA 92a preserves angiogenic capacity of HUVEC under oxidative stress. (PMID:24650666)
• The miRNA92a promoted the proliferation and migration of human neuroblastoma cells through downregulation of TrkA. (PMID:24839961)
• miR-106b-25/miR-17-92 clusters are polycistrons with oncogenic roles in hepatocellular carcinoma [review] (PMID:24876719)
• our findings indicate a regulatory role of miR-92a for WISP1 expression in pulmonary fibrosis. (PMID:24953558)
• inhibition of endothelial miR-92a attenuates neointimal lesion formation by accelerating re-endothelialization (PMID:25020912)
• Hsa-mir-93, hsa-mir-17, hsa-mir-22*, hsa-mir-126*, hsa-mir-142-3p, hsa-mir-144*, hsa-mir-486-5p, hsa-mir-451, and hsa-mir-92a were up-regulated and hsa-mir-30a, hsa-mir-382, and hsa-mir-136 were down-regulated in bromocriptine-resistant prolactinomas (PMID:25064468)
• High serum MIR92A is associated with colorectal adenocarcinoma. (PMID:25233400)
• Authors show that the previously observed downregulation of hsa-miR-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A. (PMID:25253336)
• Data indicate that coactivator-associated arginine methyltransferase 1 (CARM1) regulates neural differentiation through Nanog homeobox protein and microRNA miR92a. (PMID:25392304)
• miR-92a promoted metastasis via suppression of PTEN gene expression and activation of the PI3K/AKT pathway. (PMID:25515201)
• in patients with coronary artery disease, circulating miR-92a inversely correlates with endothelial cell-dependent, flow-mediated vasodilation and positively correlates with serum IL-1beta; findings suggest SREBP2-miR-92a-inflammasome exacerbates endothelial dysfunction during oxidative stress (PMID:25550450)
• miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion.FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells. (PMID:25623537)
• Expression of miR-92a is elevated in chondrogenic differentiation. (PMID:26135269)
• Data suggest that miR-92a is down-regulated in diabetic retinopathy; miR-92a regulates expression of PER2 (period circadian clock 2), the only clock gene needed to maintain undifferentiated state of endothelial progenitor cells. (PMID:26283734)
• In hyperuricemia, miR-92a downregulation increased KLF2 expression, subsequently inhibiting VEGFA, which resulted in decreased angiogenesis. (PMID:26299712)
• miR-92 is gradually lost in breast epithelial cells during cancer progression correlating with a shift in ERbeta1 immunoreactivity from nuclei to the cytoplasm (PMID:26437339)
• we established that miR-486 and miR-92a in association with some high-density lipoprotein (HDL) components can designate vulnerable coronary artery disease patients. (PMID:26485305)
• rs9589207 in miR-92a was highly associated with a decreased risk of GC in Chinese Han population and might serve as a novel biomarker for the disease. (PMID:26499948)
• Decreased expression of miR-20a and miR-92a in the serum from sulfur mustard-exposed patients during the chronic phase of resulting illness (PMID:26525353)
• found a significant systematic difference in expression levels between tumor zones for miR-92a, miR-424 and miR-375 (PMID:26681654)
• High expression of miR92a is associated with gastric cancer. (PMID:26790436)
• Our results revealed increased miR-92 expression and decreased ERbeta1 level in uterosacral ligaments of women diagnosed with pelvic organ prolapse. (PMID:26803387)
• Complementary effect of miR-223 and miR-92a in stool and plasma enhances the colorectal cancer detection rate. (PMID:26848774)
• findings suggest that plasma miR-92a, miR-100 and miR-143 could be promising novel circulating biomarkers in clinical detection of bladder cancer (PMID:26916216)
• Serum concentrations of exosomal miR-92a inversely correlate with human brown adipose tissue activity. (PMID:27117818)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir92a-2	ENSDARG00000082154
danio_rerio	mir92a-1	ENSDARG00000104805
rattus_norvegicus	Mir92a1	ENSRNOG00000035649

Paralogs (2): MIR25 (ENSG00000207547), MIR92A2 (ENSG00000284538)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.