MIR92A2

Summary

MIR92A2 (microRNA 92a-2, HGNC:31644) is a microRNA gene on chromosome Xq26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407049 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31644
Approved symbol	MIR92A2
Name	microRNA 92a-2
Location	Xq26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-92-2, hsa-mir-92a-2
Ensembl gene	ENSG00000284538
Ensembl biotype	miRNA
OMIM	301092
Entrez	407049
RNAcentral	URS00002E728C — miRNA, 75 nt, 21 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385299

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385299 — 1 exons

Exon	Start	End
ENSE00001500305	134169538	134169612

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Higher miR-92a-2* levels are associated with chemoresistance in small cell lung cancer. (PMID:20548249)
• The miR-92a expression varied between tumours and was inversely correlated to tumour grade and recurrence-free survival and provided independent prognostic information in multivariate Cox analysis. (PMID:22563438)
• This study revealed that miR-92a overexpression was correlated with specific colorectal cancer biopathologic features, such as TNM stage, lymph node and distant metastases, and poor survival of the patients. (PMID:22772712)
• in vivo administration of antagomiR-92a significantly enhanced re-endothelialization in injured carotid arteries and reduced neointimal formation after balloon injury or arterial stenting (PMID:22890560)
• miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion.FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells. (PMID:25623537)
• In hyperuricemia, miR-92a downregulation increased KLF2 expression, subsequently inhibiting VEGFA, which resulted in decreased angiogenesis. (PMID:26299712)
• rs9589207 in miR-92a was highly associated with a decreased risk of GC in Chinese Han population and might serve as a novel biomarker for the disease. (PMID:26499948)
• study indicated that miR-92a levels were positively associated with 24-h ambulatory blood pressure parameters, as well as carotid intima-media thickness and carotid-femoral pulse wave velocity, indicating a possible role of miR-92a in the pathogenesis of hypertension and atherosclerosis in essential hypertension (PMID:27629245)
• Results suggest that miR-92a-3p regulates cartilage development and homeostasis, which directly targets HDAC2, indicating histone hyperacetylation plays an important role in increased expression of cartilage matrix. (PMID:27884646)
• Study showed that overexpression of miR-92a was identified in osteosarcoma specimens and cells compared to normal bone tissues; miR-92a probably functions as a driver of tumor progression by targeting FBXW7. (PMID:28069547)
• The study identified a 3-miRNA panel (miR-92-3p, miR-107, and miR-3126-5p) as valuable diagnostic marker for hepatocellular carcinoma (PMID:28079796)
• Total 1208 differentially expressed genes were screened, and 5 coronary artery disease (CAD)-associated miRNAs (including miR-92a) were predicted associated with CAD. The SVM classifier was constructed based on the 41 featured genes and had high recognition efficiency. Only one lncRNA CDKN2B-antisense targeting miR-92a was obtained. (PMID:28760552)
• miR-92a is overexpressed in calcified bicuspid aortic valves, and may serve as a potential biomarker of rapid aortic valve calcification. (PMID:29092119)
• Patients with non-small cell lung cancer (NSCLC) and high plasma expression levels of miR-18a, miR-20a, and miR-92a as well as lymphatic node metastasis had a shorter overall survival than patients with low expression levels of these miRNAs. Thus, the circulating miR-18a, miR-20a, and miR-92a levels may serve as novel and promising prognostic biomarkers in patients with NSCLC. (PMID:29266846)
• These results demonstrate that adipogenesis inhibition by tumor-derived exosomes, mainly exosomal microRNAs like miR-92a-3p, are the main mediators for cancer-associated cachexia (PMID:31062357)
• Results provide evidence that cancer associated fibroblasts (CAFs) can secret miR-92a enriched exosomes into the tumor microenvironment. Exosomal miR-92a promotes migration, invasion, metastasis, stemness, and 5-FU/ L-OHP chemotherapy resistance by targeting FBXW7 and MOAP1 in colorectal cancer (CRC) cells. (PMID:31064356)
• Study reported that miR92a is upregulated in gastric carcinoma (GC) tissues. Functional analyses revealed that suppression of miR92a significantly inhibited GC cell proliferation and induced apoptosis. Further investigation suggested that inhibitor of growth protein 2 (ING2) is a direct target of miR92a. Additionally, suppression of miR92a sensitized GC cells to doxorubicin treatment. (PMID:31180538)
• The stool levels of miR-92a and miR-144* showed good sensitivity and fair specificity for detection of CRC, and thus may be useful as noninvasive biomarkers for this disease. (PMID:31216561)
• MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma. (PMID:31378903)
• circMTO1 directly interact with miR-92, and subsequently serves as a miRNA sponge to upregulate WWOX expression. (PMID:31456594)
• Results validated that colon cancer cell-derived extracellular vesicles (EVs) are enriched with miR-92a and that EVs likely induced angiogenesis through the upregulation of cell-cycle/mitosis-related genes and downregulation of adhesion-related genes, manifesting in proliferative and migratory phenotypes in endothelial cells. (PMID:31500278)
• Bone-marrow-derived cell-released extracellular vesicle miR-92a regulates hepatic pre-metastatic niche in lung cancer. (PMID:31558801)
• Study found that in lipopolysaccharide (LPS)-induced human pulmonary microvascular endothelial cells miR-92a expression was greater than in control cells. ITGA5 was found to be a target gene of miR-92a. Results reveal an important role of miR-92a in LPS-induced endothelial barrier dysfunction and suggest that miR-92a may have potential as a prognostic indicator in acute lung injury/ acute respiratory distress syndrome. (PMID:31841757)
• study revealed that miR-92a contributed to the development of progesterone resistant endometriosis by suppression of PTEN expression (PMID:31863773)
• utility of hsa-mir-92a-3p as a biomarker for sepsis-induced coagulopathy needs more verification (PMID:32075600)
• Circulating microRNA expression profiling revealed miR-92a-3p as a novel biomarker of Barrett’s carcinogenesis. (PMID:32131978)
• MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies miRNA92a as a Regulator of the LRIG1 Stem Cell Gene. (PMID:32316543)
• MicroRNA-92a promotes proliferation and invasiveness of gastric cancer cell by targeting FOXO1 gene. (PMID:32359391)
• Diagnostic value of miR-92a in asymptomatic carotid artery stenosis patients and its ability to predict cerebrovascular events. (PMID:32522208)
• MicroRNA-92a serves as a risk factor in sepsis-induced ARDS and regulates apoptosis and cell migration in lipopolysaccharide-induced HPMEC and A549 cell injury. (PMID:32534035)
• MicroRNA-92a as a marker of treatment response and survival in adult acute myeloid leukemia patients. (PMID:32536234)
• The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/beta-catenin signaling. (PMID:32587378)
• The long noncoding RNA CASC7 inhibits growth and invasion of nonsmall cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR92a. (PMID:32626930)
• Association between oxidative stress and microRNA expression pattern of ALS patients in the high-incidence area of the Kii Peninsula. (PMID:32739158)
• miR-92a-3p promotes the proliferation and invasion of gastric cancer cells by targeting KLF2. (PMID:32907305)
• High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating PTEN/Akt pathway in hepatocellular carcinoma. (PMID:32917956)
• MicroRNA-92a Inhibits the Cell Viability and Metastasis of Prostate Cancer by Targeting SOX4. (PMID:32930086)
• MicroRNA92a promotes nonsmall cell lung cancer cell growth by targeting tumor suppressor gene FBXW7. (PMID:32945381)
• Inhibition Mir-92a Alleviates Oxidative Stress and Apoptosis of Alveolar Epithelial Cells Induced by Lipopolysaccharide Exposure through TLR2/AP-1 Pathway. (PMID:33015189)
• [The value of serum microRNA-92a and microRNA-146a levels combined with pulmonary ultrasound score in predicting the severity and prognosis of acute respiratory distress syndrome]. (PMID:33198870)

Cross-species orthologs

0 orthologs

Paralogs (2): MIR25 (ENSG00000207547), MIR92A1 (ENSG00000283705)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.