MIR933

Summary

MIR933 (microRNA 933, HGNC:33676) is a microRNA gene on chromosome 2q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126350 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33676
Approved symbol	MIR933
Name	microRNA 933
Location	2q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-933
Ensembl gene	ENSG00000215973
Ensembl biotype	miRNA
Entrez	100126350
RNAcentral	URS0000759919 — miRNA, 77 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401154

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401154 — 1 exons

Exon	Start	End
ENSE00001546498	175167633	175167709

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 84.48.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.48	gold quality
bone marrow	UBERON:0002371	81.56	gold quality
blood	UBERON:0000178	81.00	gold quality
calcaneal tendon	UBERON:0003701	76.84	gold quality
islet of Langerhans	UBERON:0000006	76.13	gold quality
placenta	UBERON:0001987	75.59	gold quality
liver	UBERON:0002107	74.32	gold quality
monocyte	CL:0000576	73.45	gold quality
ectocervix	UBERON:0012249	73.29	gold quality
fallopian tube	UBERON:0003889	72.59	gold quality
granulocyte	CL:0000094	72.41	gold quality
stomach	UBERON:0000945	71.92	gold quality
gastrocnemius	UBERON:0001388	71.75	gold quality
prefrontal cortex	UBERON:0000451	71.01	gold quality
urinary bladder	UBERON:0001255	69.93	gold quality
heart	UBERON:0000948	69.90	gold quality
endometrium	UBERON:0001295	69.07	gold quality
body of pancreas	UBERON:0001150	68.81	gold quality
adult mammalian kidney	UBERON:0000082	68.68	gold quality
right lobe of liver	UBERON:0001114	68.40	gold quality
heart left ventricle	UBERON:0002084	68.24	gold quality
lung	UBERON:0002048	68.11	gold quality
right atrium auricular region	UBERON:0006631	67.99	gold quality
tibial artery	UBERON:0007610	67.99	gold quality
fundus of stomach	UBERON:0001160	67.95	gold quality
right frontal lobe	UBERON:0002810	67.38	gold quality
Ammon’s horn	UBERON:0001954	67.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.13	gold quality
substantia nigra	UBERON:0002038	67.09	gold quality
kidney	UBERON:0002113	67.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• MiR-933(rs79402775) may contribute to decreased susceptibility to GC and this SNP could be developed as a biomarker for GC prognosis. (PMID:28534360)
• TFAP2A-AS1 was revealed to act as a miRNA sponge for miR-933 and then regulated the expression of Smad2. Results from the present study suggest that TFAP2A-AS1 acts as a tumor suppressor in BC via the miR-933/SMAD2 axis. (PMID:30768589)
• hsa_circRNA_100533 regulates GNAS by sponging hsa_miR_933 to prevent oral squamous cell carcinoma. (PMID:31297884)
• Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia. (PMID:31974910)
• Aberration of the modulatory functions of intronic microRNA hsa-miR-933 on its host gene ATF2 results in type II diabetes mellitus and neurodegenerative disease development. (PMID:32993798)
• Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway. (PMID:34595235)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.