MIR934

Summary

MIR934 (microRNA 934, HGNC:33677) is a microRNA gene on chromosome Xq26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126324 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33677
Approved symbol	MIR934
Name	microRNA 934
Location	Xq26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-934
Ensembl gene	ENSG00000216060
Ensembl biotype	miRNA
OMIM	301138
Entrez	100126324
RNAcentral	URS00006AA21F — miRNA, 83 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401241 — 1 exons

Exon	Start	End
ENSE00001546585	136550878	136550960

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 73.42.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	73.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.32	gold quality
corpus callosum	UBERON:0002336	49.79	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Data show that miR-934 binds to a 3’-UTR of ubiquitin-conjugating enzyme 2N (ube2n) mRNA, down-regulated UBE2N protein expression; this, in turn, attenuated cyclin dependent kinase 6 (CDK6) protein degradation and led to CDK6 protein accumulation as well as the promotion of BC tumor growth. (PMID:31373842)
• A Five-microRNA Signature as Risk Stratification System in Uterine Corpus Endometrial Carcinoma. (PMID:32748742)
• Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer. (PMID:33213490)
• MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2. (PMID:34699325)
• Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer. (PMID:36980175)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.