MIR935

Summary

MIR935 (microRNA 935, HGNC:33678) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126325 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33678
Approved symbol	MIR935
Name	microRNA 935
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-935
Ensembl gene	ENSG00000284583
Ensembl biotype	miRNA
Entrez	100126325
RNAcentral	URS000075D91F — miRNA, 91 nt, 60 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401179

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401179 — 1 exons

Exon	Start	End
ENSE00001546523	53982307	53982397

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 85.33.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.33	gold quality
muscle of leg	UBERON:0001383	77.80	gold quality
gastrocnemius	UBERON:0001388	75.04	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.85	gold quality
body of uterus	UBERON:0009853	68.13	gold quality
putamen	UBERON:0001874	61.93	gold quality
pituitary gland	UBERON:0000007	58.91	gold quality
testis	UBERON:0000473	40.82	gold quality
left testis	UBERON:0004533	40.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• conclude that miR-935 inhibits gastric carcinoma cell proliferation, migration and invasion by targeting Notch1. (PMID:26742429)
• miR-935 contributed to cell proliferation of gastric cancer through targeting SOX7. (PMID:27044823)
• Expression of miRNA-129-2-3p was upregulated in cortical brain tissue and plasma samples from patients with refractory temporal lobe epilepsy, but miR-935 not. Plasma miRNA-129-2-3p has great potential as a non-invasive biomarker for early detection and clinical evaluation of refractory temporal lobe epilepsy. (PMID:27689807)
• Overexpression of miR-935 inhibited SOX7 expression. (PMID:27697092)
• miR-935 is down-regulated in non-small cell lung cancer tissue, is linked to poor outcome, and acts on signal transduction mediator E2F7 and the AKT pathway. (PMID:30203720)
• Findings suggest that hyaluronan (HA) fragments interact with toll like receptor 4 (TLR4) and lead macrophage polarization to an M2-like phenotype via miR-935. (PMID:30341559)
• High miR935 expression is associated with cell proliferation, migration, and invasion in colorectal cancer. (PMID:31524145)
• miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A). (PMID:33109548)
• Exosomal miR-93-5p from cancer-associated fibroblasts confers malignant phenotypes on bladder cancer cells by targeting PAFAH1B1. (PMID:36441004)
• Overexpression of microRNA-93-5p and microRNA-374a-5p Suppresses the Osteogenic Differentiation and Mineralization of Human Aortic Valvular Interstitial Cells Through the BMP2/Smad1/5/RUNX2 Signaling Pathway. (PMID:37232560)
• MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model. (PMID:37308277)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.