MIR936

Summary

MIR936 (microRNA 936, HGNC:33679) is a microRNA gene on chromosome 10q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126326 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33679
Approved symbol	MIR936
Name	microRNA 936
Location	10q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-936
Ensembl gene	ENSG00000283788
Ensembl biotype	miRNA
Entrez	100126326
RNAcentral	URS00006D1120 — miRNA, 98 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401264

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401264 — 1 exons

Exon	Start	End
ENSE00001546608	104048089	104048186

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 90.29.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	90.29	gold quality
zone of skin	UBERON:0000014	90.11	gold quality
skin of abdomen	UBERON:0001416	89.92	gold quality
ectocervix	UBERON:0012249	81.52	gold quality
vagina	UBERON:0000996	77.45	gold quality
heart left ventricle	UBERON:0002084	77.30	gold quality
placenta	UBERON:0001987	74.04	gold quality
body of stomach	UBERON:0001161	73.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.37	gold quality
esophagus mucosa	UBERON:0002469	73.36	gold quality
minor salivary gland	UBERON:0001830	73.16	gold quality
esophagus	UBERON:0001043	73.08	gold quality
stomach	UBERON:0000945	73.05	gold quality
monocyte	CL:0000576	72.12	gold quality
endometrium	UBERON:0001295	71.37	gold quality
transverse colon	UBERON:0001157	70.76	gold quality
tibial artery	UBERON:0007610	70.76	gold quality
tibial nerve	UBERON:0001323	70.70	gold quality
gastrocnemius	UBERON:0001388	70.42	gold quality
colon	UBERON:0001155	70.35	gold quality
blood	UBERON:0000178	70.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.73	gold quality
intestine	UBERON:0000160	69.60	gold quality
right frontal lobe	UBERON:0002810	68.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.52	gold quality
left ovary	UBERON:0002119	68.44	gold quality
small intestine	UBERON:0002108	68.17	gold quality
tonsil	UBERON:0002372	68.02	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.94	gold quality
omental fat pad	UBERON:0010414	67.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• MicroRNA-936 promotes proliferation and invasion of gastric cancer cells by down-regulating FGF2 expression and activating P13K/Akt signaling pathway. (PMID:32633361)
• MicroRNA-936 Targets JAG1 and Inhibits the Proliferation of Hepatocellular Carcinoma Cells. (PMID:33550933)
• Circular RNA circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis. (PMID:34057019)
• MiR-936 Targets GPR78 and Regulates Chemotherapy Resistance in Non-Small Cell Lung Cancer by Activating the Galphaq Rho GTPase Pathway. (PMID:36239568)
• Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM2.5-induced inflammatory response in human bronchial epithelial cells. (PMID:38147774)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.