MIR937

Summary

MIR937 (microRNA 937, HGNC:33680) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126338 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33680
Approved symbol	MIR937
Name	microRNA 937
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-937
Ensembl gene	ENSG00000284224
Ensembl biotype	miRNA
Entrez	100126338
RNAcentral	URS0000662FC3 — miRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401271

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401271 — 1 exons

Exon	Start	End
ENSE00001546615	143812957	143813042

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 79.72.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	79.72	gold quality
vermiform appendix	UBERON:0001154	79.58	gold quality
muscle of leg	UBERON:0001383	77.36	gold quality
blood	UBERON:0000178	75.13	gold quality
placenta	UBERON:0001987	74.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.29	gold quality
gastrocnemius	UBERON:0001388	73.61	gold quality
right atrium auricular region	UBERON:0006631	72.21	gold quality
stomach	UBERON:0000945	69.84	gold quality
body of stomach	UBERON:0001161	69.53	gold quality
thoracic aorta	UBERON:0001515	69.52	gold quality
heart left ventricle	UBERON:0002084	69.52	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.40	gold quality
ascending aorta	UBERON:0001496	69.32	gold quality
transverse colon	UBERON:0001157	68.20	gold quality
endometrium	UBERON:0001295	68.12	gold quality
lymph node	UBERON:0000029	67.82	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.15	gold quality
tibial artery	UBERON:0007610	67.11	gold quality
metanephros cortex	UBERON:0010533	67.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.73	gold quality
body of pancreas	UBERON:0001150	66.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.48	gold quality
apex of heart	UBERON:0002098	66.44	gold quality
esophagus	UBERON:0001043	66.12	gold quality
esophagus mucosa	UBERON:0002469	65.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.92	gold quality
right lobe of liver	UBERON:0001114	65.69	gold quality
amygdala	UBERON:0001876	65.67	gold quality
left coronary artery	UBERON:0001626	65.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Mechanism analyses found polyphosphate 4-phosphatase type II (INPP4B) was the target of miR-937, miR-937 directly bound to the 3’UTR of INPP4B, knockdown of INPP4B in A549 with miR-937 inhibitor promoted anchorage -dependent and -independent growth, suggesting miR-937 contributed to cell proliferation of lung cancer (PMID:27179609)
• MiR-937 could screen patients with metabolic disorders from healthy controls by targeting AMP-activated protein kinases (AMPKalpha). (PMID:31232032)
• The expression of miR-937 in peripheral blood mononuclear cells was significantly down-regulated in Kawasaki disease, which had relatively high sensitivity and specificity in predicting the coronary artery disease. (PMID:31710429)
• These results suggested that miR-937 may act as a prognostic biomarker and a potential target for therapeutic strategy, as well as promote proliferation, migration, and invasion of colon cancer (PMID:31856857)
• CircFNDC3B sequestrates miR-937-5p to derepress TIMP3 and inhibit colorectal cancer progression. (PMID:32896063)
• miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway. (PMID:33144185)
• The regulation of microRNA in each of cancer stage from two different ethnicities as potential biomarker for breast cancer. (PMID:34029828)
• Upregulation of MicroRNA-937 Predicts a Poor Prognosis and Promotes Hepatocellular Carcinoma Cell Proliferation, Migration, and Invasion. (PMID:34519997)
• MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy. (PMID:39384743)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.