MIR938

Summary

MIR938 (microRNA 938, HGNC:33681) is a microRNA gene on chromosome 10p11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126327 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33681
Approved symbol	MIR938
Name	microRNA 938
Location	10p11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-938
Ensembl gene	ENSG00000216035
Ensembl biotype	miRNA
Entrez	100126327
RNAcentral	URS00006DA7A7 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401216

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401216 — 1 exons

Exon	Start	End
ENSE00001546560	29602264	29602346

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 84.90.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	84.90	gold quality
liver	UBERON:0002107	84.70	gold quality
adrenal tissue	UBERON:0018303	84.55	gold quality
calcaneal tendon	UBERON:0003701	83.21	gold quality
kidney	UBERON:0002113	82.52	gold quality
blood	UBERON:0000178	82.03	gold quality
adult mammalian kidney	UBERON:0000082	79.40	gold quality
muscle of leg	UBERON:0001383	77.04	gold quality
gastrocnemius	UBERON:0001388	75.35	gold quality
monocyte	CL:0000576	74.96	gold quality
bone marrow	UBERON:0002371	74.63	gold quality
smooth muscle tissue	UBERON:0001135	74.12	gold quality
endometrium	UBERON:0001295	73.78	gold quality
stomach	UBERON:0000945	73.45	gold quality
apex of heart	UBERON:0002098	73.19	gold quality
adrenal gland	UBERON:0002369	72.52	gold quality
heart	UBERON:0000948	71.53	gold quality
heart left ventricle	UBERON:0002084	70.99	gold quality
left uterine tube	UBERON:0001303	70.12	gold quality
intestine	UBERON:0000160	70.02	gold quality
multicellular organism	UBERON:0000468	69.54	gold quality
right atrium auricular region	UBERON:0006631	69.51	gold quality
colon	UBERON:0001155	69.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.96	gold quality
urinary bladder	UBERON:0001255	68.78	gold quality
popliteal artery	UBERON:0002250	68.26	gold quality
tibial artery	UBERON:0007610	68.19	gold quality
ascending aorta	UBERON:0001496	68.18	gold quality
thoracic aorta	UBERON:0001515	68.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.88

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• these results suggest that polymorphisms in both IL17A and pri-miR-938 contribute to cancer risk susceptibility and therefore can affect the development of gastric cancer. (PMID:22537748)
• miR-938 promoted CRC cell proliferation by inhibiting PHLPP2 (PMID:28433657)
• The miR-938G>A polymorphisms within the seed sequence of mature miRNA were found and the seed sequence was aligned with the 3’ untranslated region (UTR) of GnRHR mRNA, a miR-938 target gene. The binding of miR-938 to the 3’-UTR of GnRHR mRNA was significantly different between normal and variant alleles. (PMID:28604625)
• Study revealed that expression of MIR938 is affected by rs12416605:C>T and that MIR938 could regulate a subset of gastric cancer-related genes in an allele-specific fashion. CXCL12, a chemokine participating in gastric cancer metastasis, is specifically regulated by only one of the rs12416605:C>T alleles. (PMID:31273931)
• Genetic Polymorphisms in miR-604A>G, miR-938G>A, miR-1302-3C>T and the Risk of Idiopathic Recurrent Pregnancy Loss. (PMID:34200157)
• Association of miRNA-492 rs2289030 G>C and miRNA-938 rs2505901 T>C Gene Polymorphisms with Biliary Atresia Susceptibility. (PMID:34353423)
• miR-938 rs2505901 T>C polymorphism increases Hirschsprung disease risk: a case-control study of Chinese children. (PMID:34761964)
• MIR938 rs2505901 T>C polymorphism is associated with increased neuroblastoma risk in Chinese children. (PMID:37905791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.