MIR940

Summary

MIR940 (microRNA 940, HGNC:33683) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126328 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33683
Approved symbol	MIR940
Name	microRNA 940
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-940
Ensembl gene	ENSG00000284346
Ensembl biotype	miRNA
Entrez	100126328
RNAcentral	URS0000699E19 — miRNA, 94 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401276

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401276 — 1 exons

Exon	Start	End
ENSE00001546620	2271747	2271840

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 73.04.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	73.04	gold quality
right lung	UBERON:0002167	72.74	gold quality
monocyte	CL:0000576	72.55	gold quality
adult mammalian kidney	UBERON:0000082	69.73	gold quality
tibial artery	UBERON:0007610	67.87	gold quality
lymph node	UBERON:0000029	67.47	gold quality
right atrium auricular region	UBERON:0006631	67.02	gold quality
body of stomach	UBERON:0001161	66.94	gold quality
endometrium	UBERON:0001295	66.83	gold quality
stomach	UBERON:0000945	65.94	gold quality
body of pancreas	UBERON:0001150	65.63	gold quality
heart left ventricle	UBERON:0002084	65.37	gold quality
blood	UBERON:0000178	65.22	gold quality
right adrenal gland	UBERON:0001233	64.68	gold quality
urinary bladder	UBERON:0001255	64.11	gold quality
left adrenal gland cortex	UBERON:0035825	64.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.15	gold quality
left uterine tube	UBERON:0001303	63.14	gold quality
right lobe of liver	UBERON:0001114	63.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.80	gold quality
nucleus accumbens	UBERON:0001882	62.69	gold quality
substantia nigra	UBERON:0002038	62.68	gold quality
lung	UBERON:0002048	62.49	gold quality
thoracic aorta	UBERON:0001515	62.30	gold quality
ascending aorta	UBERON:0001496	62.25	gold quality
left ovary	UBERON:0002119	61.94	gold quality
amygdala	UBERON:0001876	61.87	gold quality
omental fat pad	UBERON:0010414	61.77	gold quality
putamen	UBERON:0001874	61.60	gold quality
hypothalamus	UBERON:0001898	61.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 25)

• Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2. (PMID:24889693)
• MiR-940 regulates cell proliferation and survival through Nestin. (PMID:25118937)
• While MIEN1 is a direct target of miR-940, miR-940 alters MIEN1 RNA. (PMID:25406943)
• Salivary miR-3679-5p and miR-940 possess good discriminatory power to detect resectable pancreatic cancer. (PMID:25538087)
• Low level of miR-940 and high level of MyD88 in PDAC promoted PDAC cells growth which might be related to the low survival rate of PDAC patients. MiR-940 exerted its effect by targeting MyD88. (PMID:25766528)
• MiR-940 in hepatocellular carcinoma (HCC) promoted cellular proliferation via ESRRG, which may lead to the short survival period of HCC patients. (PMID:25940592)
• miR-940 promoted gastric cancer progression by directly downregulating ZNF24 expression. (PMID:26317898)
• Data show that plasma microRNA miR-940 was significantly downregulated in patients with gastric cancer. (PMID:26456959)
• This study suggested mechanistic relationship between miR-940 and Wnt/beta-catenin in the development and progression of pancreatic carcinoma through regulation of GSK3beta and sFRP1. (PMID:27459115)
• Our study found that miR-940 inhibited cellular proliferation and migration in Triple-Negative Breast Cancer cells, and the potential targeted gene was ZNF24. (PMID:27731867)
• findings present that miR-940 acts as a pivotal adaptor of CXCR2 and its transcription downregulated CXCR2 expression to decrease HCC invasion and migration in vitro. (PMID:27807540)
• Low miR940 expression is associated with ovarian cancer. (PMID:28423620)
• Tumor-derived exosomal miR940 induced by hypoxia plays an important role in stimulating tumor-associated macrophages polarization in the progression of epithelial ovarian cancer. (PMID:28586039)
• Serum downregulated miR-940 may serve as a reliable diagnostic and prognostic biomarker in breast cancer patients. (PMID:29843213)
• MiR-940 expression was decreased in non-small cell lung cancer (NSCLC) tissues. MiR-940 expression level was negatively correlated with tumor stage, size and overall survival of patients with NSCLC. In addition, miR-940 inhibited NSCLC progression by regulating its target gene FAM83F. (PMID:30280778)
• Findings suggest that miR-940/Cbl-b/STAT5a axis regulated the expression of PD-L1, which promotes the proliferation and migration of gastric cancer cells. (PMID:30367831)
• High miR940 expression is associated with proliferation and invasion of glioma. (PMID:30431124)
• The present study demonstrated that three miRNAs (miR-548q, miR-630 and miR940) might be novel and useful biomarkers for nasopharyngeal carcinoma (NPC) detection. A two-miRNA signature (miR-548q and miR940) may be considered as a better biomarker for NPC detection with relatively high sensitivity and specificity. (PMID:30475754)
• SPOCK1 overexpression promoted proliferation and invasion, and restrained apoptosis of hepatocellular carcinoma (HCC) cells. MiR-139-5p, miR-940 and miR-193a-5p inhibited HCC development through targeting SPOCK1. (PMID:30710422)
• Highly expressed microRNA-940 promotes early abortion by regulating placenta implantation by targeting ZNF672. (PMID:31002163)
• forced expression of MRVI1 in miR-940 mimic transfected cells abolished the facilitation of miR-940 on cell proliferation, migration, and invasion of RL95-2 and KLE cells. In conclusion, our study demonstrates that miR-940 might function as a reliable diagnostic and prognostic signature in endometrial carcinoma. (PMID:31085718)
• the pathogenesis of osteoarthritis can be regulated by miR-940/MyD88 axis, is reported. (PMID:31435813)
• MiR-940 promotes malignant progression of breast cancer by regulating FOXO3. (PMID:32840296)
• LncRNA GATA2-AS1 suppresses esophageal squamous cell carcinoma progression via the mir-940/PTPN12 axis. (PMID:35364057)
• hsa_circ_0038382 upregulates T-box transcription factor 5 to inhibit keloid formation by interacting with miR-940. (PMID:36413177)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.