MIR941-1
gene geneOn this page
Also known as hsa-mir-941-1
Summary
MIR941-1 (microRNA 941-1, HGNC:33684) is a microRNA gene on chromosome 20q13.33.
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
Source: NCBI Gene 100126329 — RefSeq curated summary.
At a glance
- Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:33684 |
| Approved symbol | MIR941-1 |
| Name | microRNA 941-1 |
| Location | 20q13.33 |
| Locus type | RNA, micro |
| Status | Approved |
| Aliases | hsa-mir-941-1 |
| Ensembl gene | ENSG00000283206 |
| Ensembl biotype | miRNA |
| Entrez | 100126329 |
| RNAcentral | URS00007B97D3 — miRNA, 72 nt, 2 organism(s) |
Gene structure
Transcript identifiers
Ensembl transcripts: 1 — 1 miRNA
ENST00000636396
RefSeq mRNA: 0 — MANE Select: None
Canonical transcript exons
ENST00000636396 — 1 exons
| Exon | Start | End |
|---|---|---|
| ENSE00003798314 | 63919449 | 63919520 |
Expression profiles
Bgee: expression breadth ubiquitous, 110 present calls, max score 98.98.
Top tissues by expression
110 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| sural nerve | UBERON:0015488 | 98.98 | gold quality |
| adrenal tissue | UBERON:0018303 | 91.35 | gold quality |
| skeletal muscle tissue | UBERON:0001134 | 86.75 | gold quality |
| prefrontal cortex | UBERON:0000451 | 86.62 | gold quality |
| blood | UBERON:0000178 | 84.87 | gold quality |
| bone marrow | UBERON:0002371 | 84.46 | gold quality |
| duodenum | UBERON:0002114 | 83.78 | gold quality |
| endometrium | UBERON:0001295 | 82.38 | gold quality |
| calcaneal tendon | UBERON:0003701 | 81.88 | gold quality |
| lower esophagus mucosa | UBERON:0035834 | 81.11 | gold quality |
| esophagus mucosa | UBERON:0002469 | 80.58 | gold quality |
| monocyte | CL:0000576 | 80.04 | gold quality |
| leukocyte | CL:0000738 | 79.31 | gold quality |
| liver | UBERON:0002107 | 78.87 | gold quality |
| fundus of stomach | UBERON:0001160 | 77.78 | gold quality |
| stomach | UBERON:0000945 | 77.12 | gold quality |
| esophagus | UBERON:0001043 | 76.73 | gold quality |
| right lobe of thyroid gland | UBERON:0001119 | 76.64 | gold quality |
| vermiform appendix | UBERON:0001154 | 76.35 | gold quality |
| vagina | UBERON:0000996 | 76.12 | gold quality |
| body of stomach | UBERON:0001161 | 75.72 | gold quality |
| right uterine tube | UBERON:0001302 | 75.63 | gold quality |
| small intestine | UBERON:0002108 | 75.36 | gold quality |
| apex of heart | UBERON:0002098 | 75.22 | gold quality |
| granulocyte | CL:0000094 | 75.20 | gold quality |
| body of pancreas | UBERON:0001150 | 75.09 | gold quality |
| transverse colon | UBERON:0001157 | 75.05 | gold quality |
| small intestine Peyer’s patch | UBERON:0003454 | 74.90 | gold quality |
| adult mammalian kidney | UBERON:0000082 | 74.63 | gold quality |
| muscle of leg | UBERON:0001383 | 74.43 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 0.40 |
Regulation
Is transcription factor: no
Literature-anchored findings (GeneRIF, showing 4)
- MIR941 and MIR1247 are transcriptionally regulated by DNA methylation in gastric cancer and that they have tumor suppressor properties through their inhibition of key cancer promoting genes in this context. (PMID:24785261)
- miR-941 expression was relatively higher in patients with acute coronary syndromes and ST-elevation myocardial infarction. Thus, miR-941 may be a potential biomarker of ACS or STEMI. (PMID:28830367)
- Direct evidence for transport of RNA from the mouse brain to the germline and offspring. (PMID:32354330)
- Exosomes from bone mesenchymal stem cells alleviate mifepristone-induced human endometrial stromal cell injury by inhibiting TLR3 via delivering miR-941. (PMID:36422693)
Cross-species orthologs
0 orthologs
Protein
Non-coding RNA — no protein product; not a drug target.
Function
No curated pathway, Gene-Ontology, or interaction data.
Disease & clinical
No curated disease, variant, or cancer-driver associations.
Drugs & pharmacology
No drug or pharmacology data — not an established drug target.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.