MIR941-5

Summary

MIR941-5 (microRNA 941-5, HGNC:50845) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 103504732 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50845
Approved symbol	MIR941-5
Name	microRNA 941-5
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Ensembl gene	ENSG00000275842
Ensembl biotype	miRNA
Entrez	103504732
RNAcentral	URS00007B5D6A — miRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621667

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621667 — 1 exons

Exon	Start	End
ENSE00003730685	63919868	63919939

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 89.66.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.66	gold quality
bone marrow	UBERON:0002371	73.84	gold quality
skeletal muscle tissue	UBERON:0001134	73.65	gold quality
blood	UBERON:0000178	72.85	gold quality
monocyte	CL:0000576	69.16	gold quality
leukocyte	CL:0000738	68.57	gold quality
vermiform appendix	UBERON:0001154	68.24	gold quality
placenta	UBERON:0001987	68.00	gold quality
esophagus mucosa	UBERON:0002469	66.66	gold quality
adrenal tissue	UBERON:0018303	65.35	gold quality
calcaneal tendon	UBERON:0003701	64.95	gold quality
endometrium	UBERON:0001295	64.45	gold quality
esophagus	UBERON:0001043	63.58	gold quality
muscle of leg	UBERON:0001383	63.19	gold quality
gastrocnemius	UBERON:0001388	62.85	gold quality
fundus of stomach	UBERON:0001160	62.74	gold quality
liver	UBERON:0002107	62.68	gold quality
lymph node	UBERON:0000029	62.36	gold quality
prefrontal cortex	UBERON:0000451	61.95	gold quality
body of stomach	UBERON:0001161	61.76	gold quality
stomach	UBERON:0000945	61.75	gold quality
heart left ventricle	UBERON:0002084	61.67	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	61.59	gold quality
vagina	UBERON:0000996	61.40	gold quality
adult mammalian kidney	UBERON:0000082	61.32	gold quality
pancreas	UBERON:0001264	61.28	gold quality
right adrenal gland cortex	UBERON:0035827	61.25	gold quality
granulocyte	CL:0000094	61.09	gold quality
right atrium auricular region	UBERON:0006631	60.89	gold quality
body of pancreas	UBERON:0001150	60.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR941-2 (ENSG00000216141), MIR941-4 (ENSG00000216195), MIR941-3 (ENSG00000283513)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.