MIR942

Summary

MIR942 (microRNA 942, HGNC:33688) is a microRNA gene on chromosome 1p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126331 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33688
Approved symbol	MIR942
Name	microRNA 942
Location	1p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-942
Ensembl gene	ENSG00000215930
Ensembl biotype	miRNA
Entrez	100126331
RNAcentral	URS0000712C24 — miRNA, 86 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401111

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401111 — 1 exons

Exon	Start	End
ENSE00001546455	117094643	117094728

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 88.03.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.03	gold quality
duodenum	UBERON:0002114	81.30	gold quality
calcaneal tendon	UBERON:0003701	81.19	gold quality
bone marrow	UBERON:0002371	80.15	gold quality
lymph node	UBERON:0000029	78.24	gold quality
placenta	UBERON:0001987	74.91	gold quality
islet of Langerhans	UBERON:0000006	74.85	gold quality
blood	UBERON:0000178	74.74	gold quality
kidney	UBERON:0002113	74.56	gold quality
monocyte	CL:0000576	73.91	gold quality
gastrocnemius	UBERON:0001388	73.76	gold quality
endometrium	UBERON:0001295	72.82	gold quality
liver	UBERON:0002107	72.73	gold quality
lung	UBERON:0002048	71.20	gold quality
right adrenal gland cortex	UBERON:0035827	71.19	gold quality
heart	UBERON:0000948	70.45	gold quality
anterior cingulate cortex	UBERON:0009835	70.07	gold quality
right lobe of liver	UBERON:0001114	70.06	gold quality
heart left ventricle	UBERON:0002084	69.84	gold quality
right lobe of thyroid gland	UBERON:0001119	69.63	gold quality
urinary bladder	UBERON:0001255	69.63	gold quality
left adrenal gland	UBERON:0001234	69.26	gold quality
right atrium auricular region	UBERON:0006631	69.25	gold quality
stomach	UBERON:0000945	69.19	gold quality
body of pancreas	UBERON:0001150	69.11	gold quality
rectum	UBERON:0001052	69.05	gold quality
left adrenal gland cortex	UBERON:0035825	68.53	gold quality
Ammon’s horn	UBERON:0001954	68.19	gold quality
putamen	UBERON:0001874	67.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• MiR-942 regulates hepatitis c virus-induced apoptosis of human hepatocytes by targeting ISG12a. (PMID:24727952)
• Data indicate that AKT control TRAIL resistance of cancer cells through downregulation of interferon stimulated gene 12a (ISG12a) by MicroRNA-942 (miR-942). (PMID:24970806)
• Overexpression of miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/beta-catenin signalling pathway. (PMID:25844602)
• These findings collectively illustrate that, by activating NF-kappaB signaling through upregulating a cellular miR-942-5p to target IkappaBalpha, internalized HIV-1 Vpr inhibits Kaposi’s sarcoma-associated herpesvirus lytic replication. (PMID:27440900)
• Circulating miR-942 levels were significantly lower in mid-pregnancy (12-20 weeks gestation) in women who later developed preeclampsia compared with those with an uncomplicated pregnancy. MiR-942 may be involved in the pathogenesis of preeclampsia via the regulation of its target gene ENG. (PMID:28287888)
• Data suggest that microRNA-214-3p (but not microRNA-942-5p) suppresses expression of CYP2E1 in hepatocytes; microRNA-214-3p interacts with two binding sites located in protein coding region of CYP2E1 mRNA. (CYP2E1 = cytochrome P450 family 2 subfamily E member 1) (PMID:28438567)
• miR-942 and miR-133 were confirmed as being differentially expressed in tumors of responding and non-responding patients with metastatic renal cell carcinoma treated with sunitinib (PMID:29715124)
• High hepatic miR-942 level is associated with hepatic stellate cell activation in human liver fibrosis.BAMBI is a direct target of miR-942 in the hepatic stellate cells. (PMID:30097701)
• Data show that showed that circular RNAs (circEPSTI1) and EPSTI1 (epithelial stromal interaction 1) could directly bind to miR-942. (PMID:30887698)
• miR-942-3p may act as an oncogenic factor in Hepatocellular Carcinoma cells by targeting MBL2 and provide a potential marker for patients with Hepatocellular Carcinoma. (PMID:31046434)
• Hsa-miR-942 has a role in colorectal cancer through a pathway involving Wnt3a (PMID:31278963)
• Study found miR942 expression level was overexpressed in sunitinibresistant renal cell carcinoma (RCC) and affected the expression of a number of lncRNAs and mRNAs, including lncRNA LINC00461. (PMID:31545458)
• CircRNA hsa_circ_0074834 promotes the osteogenesis-angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by acting as a ceRNA for miR-942-5p. (PMID:31804461)
• MiR-942 was a direct target of ZEB1-AS1, and it was negatively modulated by ZEB1-AS1 in HCtAEC and THP-1 cells (PMID:31962131)
• circ-CEP85L suppresses the proliferation and invasion of gastric cancer by regulating NFKBIA expression via miR-942-5p. (PMID:32026471)
• CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942. (PMID:32217695)
• MiR-942-5p alleviates septic acute kidney injury by targeting FOXO3. (PMID:32572890)
• miR-942-5p promotes the proliferation and invasion of human melanoma cells by targeting DKK3. (PMID:32772782)
• The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway. (PMID:32826876)
• Overexpression of circ_0001445 decelerates hepatocellular carcinoma progression by regulating miR-942-5p/ALX4 axis. (PMID:32856218)
• Circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of breast cancer cells in vitro and in vivo by sponging miR-942 to upregulate SOCS3. (PMID:33054543)
• Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR-942-5p and releasing DLG2 via Hippo-YAP signaling. (PMID:33128289)
• Hsa_circ_0000337 promotes proliferation, migration and invasion in glioma by competitively binding miRNA-942-5p and thus upregulates MAT2A. (PMID:33336744)
• miR-942-5p Inhibits Proliferation, Metastasis, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Targeting CCBE1. (PMID:33997050)
• lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1. (PMID:34518440)
• Circular RNA hsa_circ_0000730 restrains cell proliferation, migration, and invasion in cervical cancer through miR-942-5p/PTEN axis. (PMID:34562344)
• Long noncoding RNA SRY-box transcription factor 2 overlapping transcript participates in Parkinson’s disease by regulating the microRNA-942-5p/nuclear apoptosis-inducing factor 1 axis. (PMID:34607512)
• Circ_0007919 exerts an anti-tumor role in colorectal cancer through targeting miR-942-5p/TET1 axis. (PMID:34906917)
• Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis. (PMID:35030971)
• CircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC). (PMID:35230201)
• MiR-942-5p targeting the IFI27 gene regulates HCT-8 cell apoptosis via a TRAIL-dependent pathway during the early phase of Cryptosporidium parvum infection. (PMID:35974384)
• CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer. (PMID:36054164)
• Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis. (PMID:36434360)
• lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m[6]A reader YTHDC2. (PMID:36581942)
• Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis. (PMID:36730637)
• MiR-942-5p inhibits tumor migration and invasion through targeting CST1 in esophageal squamous cell carcinoma. (PMID:36848349)
• CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis. (PMID:37382169)
• Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis. (PMID:37515673)
• Circ_0030042 inhibits trophoblast cell growth, invasion and epithelial-mesenchymal transition process in preeclampsia via miR-942-5p/LITAF. (PMID:38262261)
• miR-942-5p Regulates Proliferation, Invasion and EMT of Trophoblast Cells in Gestational Diabetes by Targeting the CEBPA. (PMID:38290456)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.