MIR943

Summary

MIR943 (microRNA 943, HGNC:33689) is a microRNA gene on chromosome 4p16.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126332 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33689
Approved symbol	MIR943
Name	microRNA 943
Location	4p16.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-943
Ensembl gene	ENSG00000284587
Ensembl biotype	miRNA
Entrez	100126332
RNAcentral	URS000075CD07 — miRNA, 94 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401286 — 1 exons

Exon	Start	End
ENSE00001546630	1986384	1986477

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 77.82.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	77.82	gold quality
adult mammalian kidney	UBERON:0000082	72.96	gold quality
gastrocnemius	UBERON:0001388	72.26	gold quality
vagina	UBERON:0000996	71.85	gold quality
blood	UBERON:0000178	71.77	gold quality
adrenal tissue	UBERON:0018303	69.43	gold quality
left lobe of thyroid gland	UBERON:0001120	68.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.92	gold quality
heart left ventricle	UBERON:0002084	68.25	gold quality
hypothalamus	UBERON:0001898	67.48	gold quality
tibial nerve	UBERON:0001323	65.56	gold quality
body of pancreas	UBERON:0001150	65.52	gold quality
esophagus mucosa	UBERON:0002469	65.18	gold quality
saliva-secreting gland	UBERON:0001044	65.07	gold quality
tibial artery	UBERON:0007610	65.07	gold quality
left adrenal gland cortex	UBERON:0035825	64.31	gold quality
body of stomach	UBERON:0001161	64.29	gold quality
right lobe of liver	UBERON:0001114	64.26	gold quality
adrenal gland	UBERON:0002369	64.19	gold quality
transverse colon	UBERON:0001157	63.98	gold quality
multicellular organism	UBERON:0000468	63.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.56	gold quality
minor salivary gland	UBERON:0001830	62.50	gold quality
left adrenal gland	UBERON:0001234	61.89	gold quality
testis	UBERON:0000473	61.63	gold quality
right atrium auricular region	UBERON:0006631	61.37	gold quality
small intestine	UBERON:0002108	61.25	gold quality
skin of abdomen	UBERON:0001416	61.12	gold quality
ascending aorta	UBERON:0001496	60.83	gold quality
left ovary	UBERON:0002119	60.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-943-3p accelerated the progression of airway inflammation and remodeling in allergic asthma via suppressing the activity of SFRP4 through Wnt signaling pathway in asthma patients and OVA-induced mice. (PMID:31101982)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.