MIR944

Summary

MIR944 (microRNA 944, HGNC:33690) is a microRNA gene on chromosome 3q28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126340 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33690
Approved symbol	MIR944
Name	microRNA 944
Location	3q28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-944
Ensembl gene	ENSG00000216058
Ensembl biotype	miRNA
Entrez	100126340
RNAcentral	URS0000663F9C — miRNA, 88 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401239

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401239 — 1 exons

Exon	Start	End
ENSE00001546583	189829922	189830009

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 80.75.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	80.75	gold quality
muscle of leg	UBERON:0001383	76.64	gold quality
kidney	UBERON:0002113	74.48	gold quality
gastrocnemius	UBERON:0001388	74.30	gold quality
colon	UBERON:0001155	69.70	gold quality
ectocervix	UBERON:0012249	69.40	gold quality
stomach	UBERON:0000945	67.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.57	gold quality
skin of abdomen	UBERON:0001416	66.43	gold quality
zone of skin	UBERON:0000014	65.56	gold quality
blood	UBERON:0000178	65.11	gold quality
vagina	UBERON:0000996	64.94	gold quality
skin of leg	UBERON:0001511	64.47	gold quality
esophagus mucosa	UBERON:0002469	63.88	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.88	gold quality
body of stomach	UBERON:0001161	63.16	gold quality
thoracic mammary gland	UBERON:0005200	61.90	gold quality
spleen	UBERON:0002106	61.02	gold quality
right testis	UBERON:0004534	48.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• High miR-944 expression is associated with cervical cancer. (PMID:25156441)
• Expression of miR-944 and miR-3662 was upregulated in patients with lung cancer in comparison with healthy individuals. (PMID:26079400)
• The findings suggested that miR-944, as an intronic miRNA and a direct target of DeltaNp63, contributes to the function of DeltaNp63 in the induction of epidermal differentiation. (PMID:26202967)
• our study showed that miR-944 functions as a novel oncogene and regulates the cisplatin resistance in breast cancer (PMID:26298722)
• Results showed that miR-944 is a novel upstream negative regulator of SIAH1 and PTP4A1 genes and provided evidence for its functional role in migration and invasion of breast cancer cells. (PMID:27377268)
• miR-944 can be potentially used as a promising biomarker and novel therapeutic target for human endometrial cancer. (PMID:28178620)
• restoration of MACC1 expression could abrogate the anti-metastatic effects of miR-944 on colorectal cancer (CRC)cells with enhanced cell migration and invasion. MACC1/Met/AKT signaling may be implicated with the function of miR-944 in CRC cells. Altogether, miR-944 potentially act as a prognostic predictor and a drug-target for CRC patients. (PMID:28498456)
• that pri-miRNA-944 and miRNA-944 may be involved in early squamous-type differentiation of lung tumors (PMID:29496309)
• miR-944 was significantly downregulated in cancer tissues and cell lines. Upregulating miR-944 inhibited cellular proliferation and invasion in OS cells by directly targeting VEGF. (PMID:30280196)
• The overexpression of miR-944 caused G1 phase arrest and increased p53 expression in cancer cells. p53 stability was enhanced by miR-944s targeting E3 ligases COP1 and MDM2. Overexpression of COP1 and MDM2 restored cell growth inhibition caused by miR-944. (PMID:30393117)
• miR-944 is structurally combined with GATA6 and interacts with downstream proteins (CRT and p-AKT) in colorectal cells. (PMID:30873717)
• The expression levels of miR-944 in cervical cancer tissues were significantly higher compared with normal tissues. Expression levels of miR-944 in cervical cancer cell lines and tissues with human papillomavirus (HPV) infection were significantly higher compared to those without HPV infection. High miR-944 expression group showed shorter overall survival than the low miR-944 expression group in the advanced FIGO stage. (PMID:31060525)
• Long noncoding RNA SNHG14 accelerates cell proliferation, migration, invasion and suppresses apoptosis in colorectal cancer cells by targeting miR-944/KRAS axis through PI3K/AKT pathway. (PMID:31799655)
• Circulating microRNA-944 and its target gene EPHA7 as a potential biomarker for colorectal cancer. (PMID:32421395)
• Synergetic Effects of Intronic Mature miR-944 and DeltaNp63 Isoforms on Tumorigenesis in a Cervical Cancer Cell Line. (PMID:32764455)
• LncRNA SNHG6 Induces Epithelial-Mesenchymal Transition of Pituitary Adenoma Via Suppressing MiR-944. (PMID:32935999)
• MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking. (PMID:32961483)
• Long Noncoding RNA LINC00899/miR-944/ESR1 Axis Regulates Cervical Cancer Cell Proliferation, Migration, and Invasion. (PMID:34161168)
• Glioma stem cell-derived exosomal miR-944 reduces glioma growth and angiogenesis by inhibiting AKT/ERK signaling. (PMID:34233294)
• LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis. (PMID:35686740)
• Investigation of miR-133a, miR-637 and miR-944 genes expression and their relationship with PI3K/AKT signaling in women with breast cancer. (PMID:36656380)
• CIRC_0003907 MODULATES SEPSIS-INDUCED MYOCARDIAL INJURY VIA ENHANCING MYD88/NLRP3/NF-KappaB AXIS BY SPONGING MIR-944. (PMID:38010112)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.