MIR95

Summary

MIR95 (microRNA 95, HGNC:31647) is a microRNA gene on chromosome 4p16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407052 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31647
Approved symbol	MIR95
Name	microRNA 95
Location	4p16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-95
Ensembl gene	ENSG00000207807
Ensembl biotype	miRNA
OMIM	613185
Entrez	407052
RNAcentral	URS000015F70F — miRNA, 81 nt, 31 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385072

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385072 — 1 exons

Exon	Start	End
ENSE00001500078	8005301	8005381

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 90.55.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	90.55	gold quality
skeletal muscle tissue	UBERON:0001134	82.79	gold quality
adrenal tissue	UBERON:0018303	76.29	gold quality
muscle of leg	UBERON:0001383	75.84	gold quality
blood	UBERON:0000178	75.78	gold quality
gastrocnemius	UBERON:0001388	75.19	gold quality
heart left ventricle	UBERON:0002084	71.49	gold quality
stomach	UBERON:0000945	71.11	gold quality
endometrium	UBERON:0001295	70.21	gold quality
islet of Langerhans	UBERON:0000006	70.04	gold quality
body of pancreas	UBERON:0001150	68.15	gold quality
myometrium	UBERON:0001296	68.12	gold quality
heart	UBERON:0000948	67.58	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.42	gold quality
substantia nigra	UBERON:0002038	67.40	gold quality
midbrain	UBERON:0001891	67.39	gold quality
thoracic aorta	UBERON:0001515	67.24	gold quality
esophagus	UBERON:0001043	66.96	gold quality
transverse colon	UBERON:0001157	66.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.84	gold quality
esophagus mucosa	UBERON:0002469	66.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.37	gold quality
ascending aorta	UBERON:0001496	66.26	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.09	gold quality
tonsil	UBERON:0002372	66.03	gold quality
multicellular organism	UBERON:0000468	65.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.62	gold quality
adipose tissue	UBERON:0001013	65.34	gold quality
skin of abdomen	UBERON:0001416	65.30	gold quality
adult mammalian kidney	UBERON:0000082	65.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 27)

• High dose glargine alters the expression profiles of microRNA mirn95 in pancreatic cancer cells (PMID:22690071)
• miR-95 overexpression increased tumor growth and resistance to radiation treatment. (PMID:24145350)
• miR-95 functions as an oncogene role in non-small cell lung cancer cells by directly targeting SNX1. (PMID:24835695)
• We have identified for the first time two miRNAs, mir-95 and mir-190, differently expressed in serum of papillary thyroid cancer patients who in combination allow the differential diagnosis of thyroid nodules with great accuracy in our study population (PMID:25057879)
• miR-95 depletes SUMF1 protein levels and suppresses sulfatase activity, causing the disruption of proteoglycan catabolism and lysosomal function. (PMID:25524633)
• Targeting inhibition of miR-21 and miR-95 can inhibit tumor growth through elevating PTEN, SNX1, and SGPP1 expression and inhibiting Akt phosphorylation. (PMID:25831148)
• hsa-miR-665 and hsa-miR-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 and PLCG1 (PMID:25964059)
• Authors found that miR-95-3p suppressed orthotopic tumorigenicity and brain metastasis in vivo and increased overall survival and brain metastasis-free survival. (PMID:25971210)
• Data show miR95 expression level positively related to glioma grade and its downregulation affects proliferation, invasion and apoptosis by targeting CELF2. MiR95 is identified as a putative therapeutic target and CELF2 as a potential tumor suppressor. (PMID:26165303)
• Knockdown of miRNA-95 expression increased the radiosensitivity of non-small cell lung cancer (NSCLC), promoted tumor cell apoptosis and decreased cellular proliferation. In vivo assays demonstrated reduced tumor growth and resistance to radiation in tumor xenografts by downregulating miRNA-95. Study demonstrated a potential therapeutic measure of miRNA-95 as a radiosensitive marker for the treatment of NSCLC. (PMID:26915403)
• These results demonstrate that miR-95-3p is a potential new marker for Hepatocellular carcinoma and regulates hepatocarcinogenesis by directly targeting CDKN1A/p21 expression. (PMID:27698442)
• Data confirm that a combination of serum expression levels of microRNA-95 and microRNA-190 is an accurate and non-invasive tool for differential diagnosis of thyroid nodules in an Italian population. (PMID:28605303)
• Study have found that the serum expression of microRNA-95-3p was upregulated in patients with osteosarcoma. Downregulation of microRNA-95-3p expression suppresses cell growth, induced apoptosis, increased caspase-3 and caspase-9 activities and Bax/Bcl-2 protein expression in osteosarcoma cell through TGF-beta/CDKN1A/ p21/cyclin D1 expression. (PMID:29115549)
• AC-miR-95-5p-Exos may act as an HDAC2/8 inhibitor and exhibit potential as a disease-modifying osteoarthritis drug. (PMID:30063117)
• miR-95 was downregulated in gastric cancer and adjacent normal tissue samples, as well as gastric cancer cell lines. Expression of miR-95 was associated with tumor size, TNM stage and lymph node metastasis. Overexpression of miR-95 significantly suppressed cell proliferation, migration and invasion. Moreover, miR-95 inhibited epithelial-to-mesenchymal transition by directly binding the 3’-UTR of Slug. (PMID:30535480)
• MiR-95-3p promoted the development of prostatic cancer via targeting DKK3 and activating the Wnt/beta-catenin pathway (PMID:30779066)
• that miR-95-3p might act as a potential tumor suppressor in osteosarcoma by targeting hepatoma-derived growth factor (PMID:31257090)
• miR95 promotes osteosarcoma growth by targeting SCNN1A. (PMID:32323794)
• Tumor-associated macrophages promote prostate cancer progression via exosome-mediated miR-95 transfer. (PMID:32406953)
• MicroRNA-95-3p inhibits cell proliferation and metastasis in colorectal carcinoma by HDGF. (PMID:32418767)
• [Effects of microRNA95 targeting FOXD1 gene on radiosensitivity of colorectal cancer loVo cells and its mechanism]. (PMID:32744009)
• MicroRNA-95-3p serves as a contributor to cisplatin resistance in human gastric cancer cells by targeting EMP1/PI3K/AKT signaling. (PMID:33714198)
• Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis. (PMID:33974530)
• Differential Expression of Urinary Exosomal miRNA in Idiopathic Membranous Nephropathy and Evaluation of its Diagnostic Value. (PMID:35296567)
• LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects the Progression of Intervertebral Disc Degeneration. (PMID:35927800)
• Circ_0001777 Affects Triple-negative Breast Cancer Progression Through the miR-95-3p/AKAP12 Axis. (PMID:36513585)
• Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis. (PMID:36727735)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.