MIR9500

Summary

MIR9500 (microRNA 9500, HGNC:50841) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 103504730 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50841
Approved symbol	MIR9500
Name	microRNA 9500
Location	2q35
Locus type	RNA, micro
Status	Approved
Ensembl gene	ENSG00000283639
Ensembl biotype	miRNA
Entrez	103504730
RNAcentral	URS00007E4035 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635985

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635985 — 1 exons

Exon	Start	End
ENSE00003800989	218823090	218823154

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 89.03.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	89.03	gold quality
adrenal tissue	UBERON:0018303	85.72	gold quality
calcaneal tendon	UBERON:0003701	85.14	gold quality
lung	UBERON:0002048	82.50	gold quality
blood	UBERON:0000178	79.88	gold quality
muscle of leg	UBERON:0001383	78.00	gold quality
right atrium auricular region	UBERON:0006631	74.96	gold quality
gastrocnemius	UBERON:0001388	74.67	gold quality
multicellular organism	UBERON:0000468	70.87	gold quality
monocyte	CL:0000576	70.80	gold quality
liver	UBERON:0002107	70.52	gold quality
tibial artery	UBERON:0007610	68.82	gold quality
omental fat pad	UBERON:0010414	67.68	gold quality
ascending aorta	UBERON:0001496	67.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.56	gold quality
transverse colon	UBERON:0001157	67.19	gold quality
heart left ventricle	UBERON:0002084	66.87	gold quality
thoracic aorta	UBERON:0001515	66.76	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.51	gold quality
intestine	UBERON:0000160	66.46	gold quality
amygdala	UBERON:0001876	66.05	gold quality
colon	UBERON:0001155	65.44	gold quality
skin of leg	UBERON:0001511	65.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.07	gold quality
hypothalamus	UBERON:0001898	65.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.95	gold quality
anterior cingulate cortex	UBERON:0009835	64.64	gold quality
putamen	UBERON:0001874	64.61	gold quality
esophagus mucosa	UBERON:0002469	64.53	gold quality
left ovary	UBERON:0002119	64.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-9500 repressed tumorigenesis and metastasis by targeting Akt1. (PMID:24658401)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.