MIR99AHG

Summary

MIR99AHG (mir-99a-let-7c cluster host gene, HGNC:1274) is a long non-coding RNA gene on chromosome 21q21.1.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.

Source: NCBI Gene 388815 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1274
Approved symbol	MIR99AHG
Name	mir-99a-let-7c cluster host gene
Location	21q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	MONC, DILA1
Ensembl gene	ENSG00000215386
Ensembl biotype	lncRNA
OMIM	615964
Entrez	388815
RNAcentral	URS0000A770A7 — lncRNA, 4478 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 317 — 317 lncRNA

ENST00000400178, ENST00000413645, ENST00000418813, ENST00000419952, ENST00000428669, ENST00000435697, ENST00000441820, ENST00000445461, ENST00000453910, ENST00000456342, ENST00000602323, ENST00000602339, ENST00000602505, ENST00000602580, ENST00000602620, ENST00000602659, ENST00000602892, ENST00000602901, ENST00000602935, ENST00000619222, ENST00000635845, ENST00000652811, ENST00000652938, ENST00000653129, ENST00000653518, ENST00000653624, ENST00000653669, ENST00000653809, ENST00000654176, ENST00000654245, ENST00000654360, ENST00000654560, ENST00000654997, ENST00000655197, ENST00000655524, ENST00000655790, ENST00000655848, ENST00000655866, ENST00000656619, ENST00000656642, ENST00000656690, ENST00000656817, ENST00000657060, ENST00000657177, ENST00000657239, ENST00000657408, ENST00000657520, ENST00000657710, ENST00000657745, ENST00000657977, ENST00000658075, ENST00000658389, ENST00000658514, ENST00000658518, ENST00000658644, ENST00000658708, ENST00000658724, ENST00000658826, ENST00000659105, ENST00000659192, ENST00000659209, ENST00000659483, ENST00000660035, ENST00000660213, ENST00000660287, ENST00000660455, ENST00000660532, ENST00000660609, ENST00000660794, ENST00000660908, ENST00000661148, ENST00000661403, ENST00000661418, ENST00000661771, ENST00000661939, ENST00000661987, ENST00000662279, ENST00000662622, ENST00000662647, ENST00000662969, ENST00000663095, ENST00000663412, ENST00000663510, ENST00000663516, ENST00000663661, ENST00000663776, ENST00000663933, ENST00000663968, ENST00000664030, ENST00000664319, ENST00000664445, ENST00000664485, ENST00000664579, ENST00000664910, ENST00000665189, ENST00000665230, ENST00000665243, ENST00000665282, ENST00000665504, ENST00000665555, ENST00000665779, ENST00000666465, ENST00000666517, ENST00000666636, ENST00000666701, ENST00000666704, ENST00000666794, ENST00000666860, ENST00000666994, ENST00000667011, ENST00000667152, ENST00000667199, ENST00000667313, ENST00000667374, ENST00000667401, ENST00000667485, ENST00000667533, ENST00000667703, ENST00000667777, ENST00000667804, ENST00000667869, ENST00000668571, ENST00000668830, ENST00000668889, ENST00000669034, ENST00000669276, ENST00000669307, ENST00000669537, ENST00000670003, ENST00000670045, ENST00000670108, ENST00000670290, ENST00000670446, ENST00000670538, ENST00000670888, ENST00000670980, ENST00000671058, ENST00000671218, ENST00000671280, ENST00000671437, ENST00000671666, ENST00000686312, ENST00000693158, ENST00000697817, ENST00000697818, ENST00000697819, ENST00000697820, ENST00000697821, ENST00000697822, ENST00000697823, ENST00000697824, ENST00000697825, ENST00000697826, ENST00000697827, ENST00000697828, ENST00000697853, ENST00000697854, ENST00000697855, ENST00000697856, ENST00000697857, ENST00000697870, ENST00000697871, ENST00000697872, ENST00000697873, ENST00000697874, ENST00000697875, ENST00000697876, ENST00000697877, ENST00000697878, ENST00000697879, ENST00000697880, ENST00000697933, ENST00000697934, ENST00000697935, ENST00000697936, ENST00000697937, ENST00000697938, ENST00000697939, ENST00000697940, ENST00000697941, ENST00000697942, ENST00000697943, ENST00000697944, ENST00000697945, ENST00000697946, ENST00000697947, ENST00000697948, ENST00000697949, ENST00000697950, ENST00000697951, ENST00000697952, ENST00000697969, ENST00000697970, ENST00000697971, ENST00000697972, ENST00000697973, ENST00000697974, ENST00000697975, ENST00000697976, ENST00000697977, ENST00000697978, ENST00000697979, ENST00000697980, ENST00000697981, ENST00000697982, ENST00000697983, ENST00000697984, ENST00000697985, ENST00000697986, ENST00000698000, ENST00000698001, ENST00000698002, ENST00000698003, ENST00000698004, ENST00000698005, ENST00000698006, ENST00000698007, ENST00000698008, ENST00000698049, ENST00000698050, ENST00000698051, ENST00000698052, ENST00000698061, ENST00000698062, ENST00000698063, ENST00000698064, ENST00000698065, ENST00000698066, ENST00000698067, ENST00000698068, ENST00000698093, ENST00000698094, ENST00000698095, ENST00000698096, ENST00000698109, ENST00000698110, ENST00000698111, ENST00000698121, ENST00000698122, ENST00000698123, ENST00000698124, ENST00000698125, ENST00000698126, ENST00000698127, ENST00000698161, ENST00000698162, ENST00000698163, ENST00000698164, ENST00000698165, ENST00000698166, ENST00000698167, ENST00000698168, ENST00000701019, ENST00000701157, ENST00000701373, ENST00000701389, ENST00000701447, ENST00000701495, ENST00000731390, ENST00000731391, ENST00000731392, ENST00000731393, ENST00000731394, ENST00000731395, ENST00000731396, ENST00000731397, ENST00000731398, ENST00000731399, ENST00000731400, ENST00000731401, ENST00000731402, ENST00000731403, ENST00000731404, ENST00000731405, ENST00000731406, ENST00000731407, ENST00000731408, ENST00000731409, ENST00000731410, ENST00000731411, ENST00000731412, ENST00000731413, ENST00000731414, ENST00000731415, ENST00000731416, ENST00000731417, ENST00000731418, ENST00000731419, ENST00000731420, ENST00000731421, ENST00000731422, ENST00000731423, ENST00000731424, ENST00000731425, ENST00000731426, ENST00000731427, ENST00000731428, ENST00000731429, ENST00000731430, ENST00000731431, ENST00000731432, ENST00000731433, ENST00000731434, ENST00000731435, ENST00000731436, ENST00000731437, ENST00000731438, ENST00000731439, ENST00000731440, ENST00000731441, ENST00000731442, ENST00000731443, ENST00000731444, ENST00000731445, ENST00000731446, ENST00000731447, ENST00000731448

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000400178 — 7 exons

Exon	Start	End
ENSE00001494058	16181591	16181687
ENSE00001625593	16231056	16231115
ENSE00001715598	16071114	16071398
ENSE00001758912	16391614	16391685
ENSE00001789031	16487490	16487538
ENSE00003855497	16070672	16070892
ENSE00003856716	16606994	16607135

Expression profiles

Bgee: expression breadth ubiquitous, 235 present calls, max score 98.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.5953 / max 545.4373, expressed in 1250 samples.

FANTOM5 promoters (46 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188550	1.9691	593
188538	1.3048	473
188554	0.9827	386
188532	0.9137	447
188537	0.8418	403
188552	0.7907	324
188539	0.5500	266
188521	0.4961	147
188562	0.4219	215
188533	0.4090	199

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.99	gold quality
tendon	UBERON:0000043	97.93	gold quality
tendon of biceps brachii	UBERON:0008188	97.33	gold quality
ganglionic eminence	UBERON:0004023	96.74	gold quality
ventricular zone	UBERON:0003053	96.35	gold quality
left ovary	UBERON:0002119	96.01	gold quality
right ovary	UBERON:0002118	95.33	gold quality
adrenal tissue	UBERON:0018303	95.22	gold quality
body of uterus	UBERON:0009853	94.53	gold quality
sural nerve	UBERON:0015488	94.45	gold quality
endocervix	UBERON:0000458	94.36	gold quality
ectocervix	UBERON:0012249	93.67	gold quality
uterine cervix	UBERON:0000002	93.54	gold quality
ovary	UBERON:0000992	92.91	gold quality
right atrium auricular region	UBERON:0006631	92.01	gold quality
left uterine tube	UBERON:0001303	91.95	gold quality
vagina	UBERON:0000996	91.20	gold quality
prostate gland	UBERON:0002367	90.83	gold quality
oviduct epithelium	UBERON:0004804	90.43	gold quality
adenohypophysis	UBERON:0002196	90.33	gold quality
cardiac atrium	UBERON:0002081	90.23	gold quality
heart left ventricle	UBERON:0002084	89.93	gold quality
gall bladder	UBERON:0002110	89.58	gold quality
right uterine tube	UBERON:0001302	89.48	gold quality
heart	UBERON:0000948	89.45	gold quality
cardiac ventricle	UBERON:0002082	89.32	gold quality
right coronary artery	UBERON:0001625	89.21	gold quality
apex of heart	UBERON:0002098	88.99	gold quality
tibial nerve	UBERON:0001323	88.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	88.62	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-GEOD-131882	yes	5346.35
E-GEOD-180759	yes	3213.41
E-HCAD-35	yes	93.63
E-HCAD-25	yes	25.80
E-ANND-3	yes	15.13
E-CURD-119	yes	13.98

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): RARA

Literature-anchored findings (GeneRIF, showing 6)

• This study reveals an unprecedented function of long non-coding RNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. (PMID:25027842)
• MIR99AHG is a noncoding tumor suppressor gene in lung adenocarcinoma. (PMID:33931593)
• Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of Mycobacterium tuberculosis. (PMID:35895506)
• LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets. (PMID:36782197)
• A novel LINC00478 serves as a tumor suppressor in endometrial carcinoma progression. (PMID:37603104)
• The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells. (PMID:37725664)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.