MIRLET7A1HG

Summary

MIRLET7A1HG (miRlet-7a-1/let-7f-1/let-7d cluster host gene, HGNC:53970) is a long non-coding RNA gene on chromosome 9q22.32.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.

Source: NCBI Gene 112903833 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53970
Approved symbol	MIRLET7A1HG
Name	miRlet-7a-1/let-7f-1/let-7d cluster host gene
Location	9q22.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000269929
Ensembl biotype	lncRNA
Entrez	112903833
RNAcentral	URS0002123205 — lncRNA, 528 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000602703, ENST00000652620, ENST00000652769, ENST00000657255, ENST00000710611, ENST00000711292, ENST00000803408, ENST00000803409, ENST00000803410, ENST00000803411, ENST00000803412, ENST00000803413, ENST00000803414, ENST00000803415, ENST00000803416, ENST00000803417, ENST00000803418, ENST00000803419, ENST00000803420, ENST00000803421, ENST00000803422

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000602703 — 2 exons

Exon	Start	End
ENSE00004012556	94166274	94166381
ENSE00004012557	94200486	94200905

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 87.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.3503 / max 657.1507, expressed in 1806 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
97449	21.0966	1805
97448	1.2537	623

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	87.86	gold quality
left lobe of thyroid gland	UBERON:0001120	86.38	gold quality
thyroid gland	UBERON:0002046	85.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.93	gold quality
mucosa of transverse colon	UBERON:0004991	83.68	gold quality
apex of heart	UBERON:0002098	83.65	gold quality
right lung	UBERON:0002167	82.60	gold quality
cortex of kidney	UBERON:0001225	82.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.94	gold quality
lower esophagus	UBERON:0013473	81.88	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.72	gold quality
spleen	UBERON:0002106	81.64	gold quality
calcaneal tendon	UBERON:0003701	81.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.25	gold quality
right uterine tube	UBERON:0001302	81.20	gold quality
right coronary artery	UBERON:0001625	81.01	gold quality
skeletal muscle tissue	UBERON:0001134	80.91	gold quality
muscle layer of sigmoid colon	UBERON:0035805	80.69	gold quality
monocyte	CL:0000576	80.63	gold quality
left uterine tube	UBERON:0001303	80.47	gold quality
endometrium	UBERON:0001295	80.34	gold quality
left coronary artery	UBERON:0001626	80.32	gold quality
thoracic aorta	UBERON:0001515	80.27	gold quality
ascending aorta	UBERON:0001496	80.18	gold quality
muscle of leg	UBERON:0001383	80.15	gold quality
metanephros cortex	UBERON:0010533	80.12	gold quality
muscle tissue	UBERON:0002385	80.09	gold quality
leukocyte	CL:0000738	79.97	gold quality
upper lobe of left lung	UBERON:0008952	79.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SNORD11B-mediated 2’-O-methylation of primary let-7a in colorectal carcinogenesis. (PMID:37620450)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.