MIRLET7A2

Summary

MIRLET7A2 (microRNA let-7a-2, HGNC:31477) is a microRNA gene on chromosome 11q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406882 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31477
Approved symbol	MIRLET7A2
Name	microRNA let-7a-2
Location	11q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-let-7a-2
Ensembl gene	ENSG00000198975
Ensembl biotype	miRNA
OMIM	612142
Entrez	406882
RNAcentral	URS00003F0B88 — miRNA, 72 nt, 23 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362105

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362105 — 1 exons

Exon	Start	End
ENSE00001436868	122146522	122146593

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 80.19.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	80.19	gold quality
kidney	UBERON:0002113	79.19	gold quality
adrenal tissue	UBERON:0018303	77.33	gold quality
endometrium	UBERON:0001295	77.04	gold quality
blood	UBERON:0000178	76.24	gold quality
stomach	UBERON:0000945	75.50	gold quality
liver	UBERON:0002107	74.06	gold quality
left uterine tube	UBERON:0001303	73.32	gold quality
body of stomach	UBERON:0001161	71.90	gold quality
monocyte	CL:0000576	71.20	gold quality
intestine	UBERON:0000160	71.02	gold quality
corpus callosum	UBERON:0002336	70.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.15	gold quality
heart	UBERON:0000948	69.97	gold quality
substantia nigra	UBERON:0002038	69.87	gold quality
gastrocnemius	UBERON:0001388	69.83	gold quality
lung	UBERON:0002048	69.29	gold quality
hypothalamus	UBERON:0001898	69.01	gold quality
thoracic aorta	UBERON:0001515	68.38	gold quality
tibial artery	UBERON:0007610	68.35	gold quality
ascending aorta	UBERON:0001496	68.31	gold quality
colon	UBERON:0001155	68.04	gold quality
descending thoracic aorta	UBERON:0002345	67.99	gold quality
adipose tissue	UBERON:0001013	67.79	gold quality
omental fat pad	UBERON:0010414	67.78	gold quality
transverse colon	UBERON:0001157	67.48	gold quality
right atrium auricular region	UBERON:0006631	66.78	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.68	gold quality
brain	UBERON:0000955	66.38	gold quality
Ammon’s horn	UBERON:0001954	66.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.20

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CEBPA, VDR

Literature-anchored findings (GeneRIF, showing 22)

• The characterization and functional analysis of the promoter of the human miRNA let-7a2 in A549 cell lines, is reported. (PMID:21365266)
• data indicated that 1,25-(OH)2VD3 could upregulate the transcription of hsa-let-7a-2 in lung cancer cells and the up-regulation of hsa-let-7a-2 expression induced by 1,25-(OH)2VD3 might mediate the anti-proliferation effects of 1,25-(OH)2VD3 in lung cancer cells (PMID:23566834)
• esults indicate that both Sp1 and PARP1 contribute to FBN1 gene expression. These observations add to our understanding of the transcriptional regulation of FBN1 gene expression (PMID:23860321)
• Results show that microRNAs Let-7a and miR-335 expression levels were significantly downregulated in the tumors of patients with a BRCA mutation and correlated with tumor prognosis. (PMID:24942235)
• Results show that LOX-1 is a target of let- 7a and let-7b, and they inhibit the expression of LOX-1 by targeting its 3’-UTR. (PMID:25247304)
• overexpression of Lin28 can suppress the biological behavior of gastric cancer in vitro, and let-7 miRNA may play an important role in the process (PMID:25515921)
• High let-7a-2-3p and low miR-188-5p expression could be potentially used as favorably prognostic biomarkers. (PMID:25646775)
• Results show evidence that let-7a expression in osteosarcoma (OS) cells is significantly reduced and inversely correlated with E2F2 expression levels and that let-7a plays an important role in OS cell proliferation and tumorigenesis by targeting E2F2. (PMID:25647078)
• Plasma miR-20a and let-7a levels are significantly altered in patients with ESCC and can be used as potential biomarkers in the diagnosis of esophageal squamous cell carcinoma. (PMID:25914476)
• Our current findings identify a regulatory network of miR let-7a-USP35-ABIN-2 pathway, which may serve as potential therapeutic targets to help us control the human cancer progression (PMID:26348204)
• let-7 is a tumor suppressor that negatively regulates RAS, also in Ewing Sarcoma, and HIF-1alpha may contribute to the aggressive metastatic behavior of Ewing Sarcoma (PMID:26393682)
• These findings uncover a miR-372/let-7 axis regulating human primordial germ cell (PGC) specification. (PMID:27066911)
• Let-7a inhibition by HBV mRNAs resulted in enhanced HCC cell colony formation and tumor growth, providing evidence of the oncogenic potential of HBV mRNAs. (PMID:27693636)
• TGF-beta induces MIR100HG lncRNA, encoding miR-100, let-7a and miR-125b that control pancreatic ductal adenocarcinoma tumorigenesis. Pro-tumorigenic miR-100 and miR-125b increase and anti-tumorigenic let-7a is unchanged, as TGF-beta also induces LIN28B. The induction of LIN28B results in the up-regulation of miR-100 and miR-125b, with let-7a unchanged despite being part of the same MIR100HG primary transcript. (PMID:29748571)
• Expression of let-7a-5p in pneumoconiosis is downregulated, while reduced let-7a-5p corresponds to high expression of BCL2L1 and poor survival of lung adenocarcinoma patients. (PMID:30497474)
• Inhibition effect of exosomes-mediated Let-7a on the development and metastasis of triple negative breast cancer by down-regulating the expression of c-Myc. (PMID:31298382)
• Study provides evidence that let-7a miRNA positively regulates translational readthrough of AGO1. (PMID:31330067)
• Salivary miR-let-7a-5p and miR-3928 were significantly down regulated in saliva of head and neck squamous cell carcinoma patients, and have the potential to be novel non-invasive biomarkers for early detection and prognosis head and neck squamous cell carcinoma. (PMID:32208417)
• Let-7a-5p represses proliferation, migration, invasion and epithelial-mesenchymal transition by targeting Smad2 in TGF-b2-induced human lens epithelial cells. (PMID:32345785)
• Predictive Value of let-7a for Cancer Cell Repopulation between Chemotherapy and Long-Term Survival: A Prospective Study. (PMID:34686505)
• Pre-miRNA Hsa-Let-7a-2: a Novel Intracellular Partner of Angiotensin II Type 2 Receptor Negatively Regulating its Signals. (PMID:35637969)
• LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network. (PMID:37596700)

Cross-species orthologs

0 orthologs

Paralogs (10): MIRLET7E (ENSG00000198972), MIRLET7C (ENSG00000199030), MIRLET7F1 (ENSG00000199072), MIRLET7D (ENSG00000199133), MIRLET7G (ENSG00000199150), MIRLET7A1 (ENSG00000199165), MIRLET7I (ENSG00000199179), MIRLET7F2 (ENSG00000208012), MIR98 (ENSG00000271886), MIRLET7A3 (ENSG00000283990)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.