MIRLET7BHG

Summary

MIRLET7BHG (MIRLET7B and MIRLET7A3 host gene, HGNC:37189) is a long non-coding RNA gene on chromosome 22q13.31.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Implicated in lung cancer.

Source: NCBI Gene 400931 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37189
Approved symbol	MIRLET7BHG
Name	MIRLET7B and MIRLET7A3 host gene
Location	22q13.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-Ppara
Ensembl gene	ENSG00000197182
Ensembl biotype	lncRNA
OMIM	618216
Entrez	400931
RNAcentral	URS000075C708 — lncRNA, 4717 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 43 — 43 lncRNA

ENST00000360737, ENST00000381051, ENST00000416202, ENST00000435439, ENST00000443490, ENST00000445441, ENST00000451166, ENST00000608644, ENST00000686090, ENST00000686105, ENST00000686767, ENST00000687637, ENST00000691934, ENST00000715840, ENST00000794298, ENST00000794299, ENST00000794300, ENST00000794301, ENST00000794302, ENST00000794303, ENST00000794304, ENST00000794305, ENST00000794306, ENST00000794307, ENST00000794308, ENST00000794309, ENST00000794310, ENST00000794311, ENST00000794312, ENST00000794313, ENST00000794314, ENST00000794315, ENST00000794316, ENST00000794317, ENST00000794318, ENST00000794319, ENST00000794320, ENST00000794321, ENST00000794322, ENST00000794323, ENST00000794324, ENST00000794325, ENST00000794326

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000360737 — 5 exons

Exon	Start	End
ENSE00001408108	46097926	46098010
ENSE00001412318	46109764	46113928
ENSE00001869746	46086003	46086160
ENSE00003755342	46109267	46109353
ENSE00003755452	46098494	46098558

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 90.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.3032 / max 84.8145, expressed in 991 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192772	9.4686	1523
192783	2.3129	815
192784	1.3332	666
192787	0.9499	354
192771	0.6569	389
192788	0.4644	260
209507	0.2428	120
192773	0.0491	22

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	90.01	gold quality
upper arm skin	UBERON:0004263	89.59	silver quality
skin of abdomen	UBERON:0001416	81.25	gold quality
buccal mucosa cell	CL:0002336	81.13	silver quality
colonic epithelium	UBERON:0000397	80.67	gold quality
skin of leg	UBERON:0001511	80.21	gold quality
corpus callosum	UBERON:0002336	79.95	gold quality
cerebellar vermis	UBERON:0004720	79.48	silver quality
zone of skin	UBERON:0000014	79.20	gold quality
uterine cervix	UBERON:0000002	78.79	gold quality
ascending aorta	UBERON:0001496	78.26	gold quality
tibia	UBERON:0000979	78.23	gold quality
lateral globus pallidus	UBERON:0002476	78.05	gold quality
left ovary	UBERON:0002119	77.98	gold quality
ectocervix	UBERON:0012249	77.88	gold quality
thoracic aorta	UBERON:0001515	77.77	gold quality
stromal cell of endometrium	CL:0002255	77.71	gold quality
substantia nigra pars compacta	UBERON:0001965	77.48	gold quality
body of tongue	UBERON:0011876	77.43	gold quality
vena cava	UBERON:0004087	77.37	gold quality
aorta	UBERON:0000947	77.30	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	77.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.05	gold quality
popliteal artery	UBERON:0002250	76.98	gold quality
tibial artery	UBERON:0007610	76.97	gold quality
right lung	UBERON:0002167	76.93	gold quality
visceral pleura	UBERON:0002401	76.91	silver quality
pharyngeal mucosa	UBERON:0000355	76.89	gold quality
substantia nigra pars reticulata	UBERON:0001966	76.75	gold quality
nipple	UBERON:0002030	76.75	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.