MIRLET7E

Summary

MIRLET7E (microRNA let-7e, HGNC:31482) is a microRNA gene on chromosome 19q13.41.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406887 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31482
Approved symbol	MIRLET7E
Name	microRNA let-7e
Location	19q13.41
Locus type	RNA, micro
Status	Approved
Aliases	hsa-let-7e
Ensembl gene	ENSG00000198972
Ensembl biotype	miRNA
OMIM	611250
Entrez	406887
RNAcentral	URS000075DE48 — miRNA, 79 nt, 23 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362102

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362102 — 1 exons

Exon	Start	End
ENSE00001436865	51692786	51692864

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 78.21.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.21	gold quality
midbrain	UBERON:0001891	73.90	gold quality
amygdala	UBERON:0001876	71.44	gold quality
sural nerve	UBERON:0015488	70.95	gold quality
tibial artery	UBERON:0007610	64.59	gold quality
heart left ventricle	UBERON:0002084	62.43	gold quality
heart	UBERON:0000948	62.39	gold quality
cerebellum	UBERON:0002037	59.65	gold quality
thyroid gland	UBERON:0002046	57.86	gold quality
epididymis	UBERON:0001301	56.87	silver quality
vagina	UBERON:0000996	56.25	gold quality
uterus	UBERON:0000995	55.84	gold quality
renal glomerulus	UBERON:0000074	55.78	silver quality
placenta	UBERON:0001987	53.75	gold quality
prostate gland	UBERON:0002367	52.79	silver quality
testis	UBERON:0000473	52.17	silver quality
islet of Langerhans	UBERON:0000006	51.59	silver quality
omental fat pad	UBERON:0010414	50.93	gold quality
pituitary gland	UBERON:0000007	45.18	gold quality
ovary	UBERON:0000992	42.65	gold quality
adenohypophysis	UBERON:0002196	36.04	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): KDM5B

Literature-anchored findings (GeneRIF, showing 26)

• JARID1B demethylase contributes to tumor cell proliferation through the epigenetic repression of a tumor suppressor miR (PMID:21969366)
• findings show the rs10889677 variant in the 3’-untranslated region of IL-23R gene displays enhanced levels of both mRNA and production of IL-23R; this can be attributed to loss of binding capacity for the microRNAs Let-7e and Let-7f by the variant allele (PMID:22262659)
• MIRNlet7e was associated with severe osteoarthritis requiring arthroplasty. (PMID:24515954)
• Lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. (PMID:24945821)
• Data indicate that knockdown of let-7b or let-7e could recover the growth rate and the invasion of cofilin-1 over-expressing cells. (PMID:25597880)
• Changes in the plasma level of Let-7e could represent early markers of metabolic dysfunction in children with MetS traits (PMID:26046362)
• let-7e may be associated with the pathogenesis of Hashimoto’s disease through the regulation of intracellular IL-10 expression. (PMID:26821743)
• The study identified Fas ligand (FASLG) as the target of let-7e-5p, and FASLG knockdown increased the migration and tube formation of endothelial progenitor cell. (PMID:26826505)
• NEAT1 promoted oncogenesis by downregulating let-7e expression in glioma stem cells. (PMID:27556696)
• The present study revealed let-7e as a pro-inflammatory mediator and a novel regulatory mechanism for the NF-kappaB pathway through ceRNA crosstalk, comprising let-7e and its target IkappaBbeta and the ceRNA lnc-MKI67IP-3. (PMID:28195197)
• In epithelial ovarian cancer, low let-7e leads to activation of BRCA1 and Rad51 expression and subsequent enhancement of DSB repair. (PMID:28376831)
• ARID3A was down-regulated by ZEB1 in a miR-99b/let-7e/miR-125a dependent mannerto promotes invasion and metastasis in esophageal squamous cell carcinoma. (PMID:28408353)
• Concentrations of all let-7 miRNAs let-7a, let-7b, let-7c, let-7d, let-7e and let-7g were significantly higher in urine samples obtained from renal cell carcinoma (RCC) patients compared to healthy controls. (PMID:28694731)
• altered expression of miR-33a/let-7e was correlated with ST8SIA1 level, which might contribute to CRC progression (PMID:28751193)
• These findings indicate that the let-7e/EZH2/H3K27me3/NF-kappaB p65 pathway is a novel regulatory axis of TNF-alpha expression. (PMID:29768655)
• both IGF1 and IGF1R mRNA are potential targets for let-7 miRNA family. (PMID:29886785)
• In CSF from Alzheimer s disease (AD) patients, let-7b and let-7e were associated with extracellular vesicles. let-7 family members present in the CSF mediated neurotoxicity in vitro, albeit to a variable extent. Taken together, neurotoxic let-7 miRNAs are differentially and specifically released in AD. (PMID:30011310)
• our findings identified the miR-125a99blet-7e cluster as a new key intracellular mediator used by the master anti-inflammatory cytokine IL-10 to dampen down the pro-inflammatory TLR pathway and provides a new perspective in the understanding of mechanisms by which the inflammatory response is regulated in phagocytes. (PMID:30245693)
• Authors report a novel mechanism by which endothelial miR-125a and let-7e-mediated regulation of interleukin-6 (IL-6) signaling can manipulate vasculogenic mimicry (VM) formation of MDA-MB-231 breast cancer cells. We found that endothelial IL-6 levels were significantly higher in response to cisplatin treatment, whereas levels of IL-6 upon cisplatin exposure remained unchanged in MDA-MB-231 breast cancer cells. (PMID:30670152)
• Let-7e plays an important role as tumor suppressor miRNA in colorectal cancer cells probably through inhibition of DCLK1 expression. (PMID:31075231)
• Levels of miR-146a and miR-155 in monocytes were lower in major depressive disorder patients than in controls and were increased in the former after antidepressant treatment. Multiple linear regression analyses found that let-7e and miR-146a expression before treatment was inversely correlated with severity of depression, whereas miR-155 before treatment was directly correlated with severity of depression. (PMID:31252530)
• Studied association of single nucleotide polymorphism (SNP)rs10889677 in the microRNA let-7e and let-7f binding site of interleukin 23 receptor (IL23R) with genetic predisposition to colorectal cancer. (PMID:31546198)
• Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1. (PMID:31722968)
• microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner. (PMID:33299140)
• Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism. (PMID:34246727)
• A glimpse into let-7e roles in human disorders; friend or foe? (PMID:38103367)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mirlet7e	ENSMUSG00000105758

Paralogs (10): MIRLET7A2 (ENSG00000198975), MIRLET7C (ENSG00000199030), MIRLET7F1 (ENSG00000199072), MIRLET7D (ENSG00000199133), MIRLET7G (ENSG00000199150), MIRLET7A1 (ENSG00000199165), MIRLET7I (ENSG00000199179), MIRLET7F2 (ENSG00000208012), MIR98 (ENSG00000271886), MIRLET7A3 (ENSG00000283990)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.