MIRLET7F1

Summary

MIRLET7F1 (microRNA let-7f-1, HGNC:31483) is a microRNA gene on chromosome 9q22.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406888 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31483
Approved symbol	MIRLET7F1
Name	microRNA let-7f-1
Location	9q22.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-let-7f-1
Ensembl gene	ENSG00000199072
Ensembl biotype	miRNA
OMIM	612146
Entrez	406888
RNAcentral	URS00004BFD1E — miRNA, 87 nt, 55 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362202

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362202 — 1 exons

Exon	Start	End
ENSE00001436965	94176347	94176433

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 68.87.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	68.87	gold quality
blood	UBERON:0000178	63.80	gold quality
tibial artery	UBERON:0007610	62.51	gold quality
lung	UBERON:0002048	58.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 32)

• let-7f miRNA regulates baseline beta(2)AR expression and decreases in let-7f evoked by agonist attenuate down-regulation. (PMID:21447718)
• Data show that Let-7f blocks IL-23R expression through its complementary target sequence within 3’ untranslated region of target gene. (PMID:21508257)
• TIMP-1 is a direct regulator of human mesenchymal stem cells functions and reveal a regulatory network in which let-7f modulates Wnt/beta-catenin activity. (PMID:22223664)
• findings show the rs10889677 variant in the 3’-untranslated region of IL-23R gene displays enhanced levels of both mRNA and production of IL-23R; this can be attributed to loss of binding capacity for the microRNAs Let-7e and Let-7f by the variant allele (PMID:22262659)
• miR-205 and let-7f are biomarkers for ovarian cancer and may be predictive of ovarian cancer prognosis. (PMID:24223734)
• MiR-let-7f-1 is differentially expressed with cisplatin treatment in SPARC expressed cells. (PMID:25014664)
• let-7f silencing led to the increased expression of the hepatocyte-specific factors and accelerated adipose tissue-derived stem cell hepatic differentiation (PMID:25077652)
• Study show that Let-7f is down-regulated in glioma tissue and cell lines; its enhanced expression suppresses glioma cells proliferation, migration, and invasion via direct targeting perisotin suggesting it as an important role in glioma pathogenesis. (PMID:25735962)
• The combination of serum let-7b, 7d, and 7f levels during the proliferative phase may serve as a diagnostic marker for endometriosis. (PMID:25772772)
• Data suggest that promoter activity/expression of miRNA let-7 gene cluster in skeletal muscle satellite cells are up-regulated in response to glucose, TNFa (tumor necrosis factor-alpha), and caffeine (but not insulin). (PMID:26378151)
• miRlet7f1 is involved in the anticancer effects of lycopene and serves an important role in the inhibition of prostate cancer progression through the downregulation of AKT2. (PMID:26847233)
• Aromatase inhibitor treatment significantly increased expression of let-7f in Ishikawa cells and endometrial stroma cells from patients with endometriosis. (PMID:27320036)
• Cigarette smoke exposure is associated with reduced expression of let-7f and activation of the anti-angiogenic TGF-beta/ALK5 pathway. (PMID:28345812)
• The expression levels of let-7f-5p, miR-5100 and miR-25-3p were significantly associated with the incidence rate of cALL, and these miRNAs might serve as promising biomarkers for cALL[Precursor Cell Lymphoblastic Leukemia-Lymphoma]. (PMID:28910942)
• let-7f-1 is a direct target of transcription factor, C/EBPbeta in endocervical epithelial cells (PMID:28921745)
• identified a system through which TLR3 mediated immune response is regulated by C/EBPbeta and let-7f through the temporal activation of MAPK and NF-kappaB in human endocervical cells. (PMID:29323736)
• In the risk study, the let-7i rs10877887 and let-7a-1/let-7f-1/let-7d rs13293512 were shown no significant association for the overall cancer risk. In the stratified analysis, the rs10877887 variant genotype was significantly associated with a decreased cancer risk in head and neck cancer. (PMID:29717029)
• Study identified hsalet7gf-1 to regulate the expression of TRPM6 in colorectal neoplasm. (PMID:30272358)
• Study in human small airway epithelial cells (HSAEC) and human pulmonary alveolar epithelial cells (HPAEpiC) revealed that smoke exposure significantly reduced Let-7f-1-3p expression level in HSAEC and HPAEpiC. FOXO1 was verified as a putative regulatory target of Let-7f-1-3p. Let-7f-1-3p attenuates smoke-induced apoptosis in HSAEC and HPAEpiC by targeting FOXO1. (PMID:31301310)
• let-7f-5p functions as a potential inhibitor of Th17 differentiation in the pathogenesis of multiple sclerosis by targeting STAT3 (PMID:31326963)
• let-7f-5p upregulation ameliorated inflammation through modulating NLRP3. (PMID:31545233)
• Significant levels of circulating let-7f (p = 0.048) were found in Abdominal Aortic Aneurysm patients compared to peripheral arterial disease patients with no significant correlation with aortic diameter (R(2) = 0.03). (PMID:31694153)
• Downregulation of microRNA let-7f mediated the Adriamycin resistance in leukemia cell line. (PMID:31793054)
• Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus. (PMID:32133007)
• Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway. (PMID:32305960)
• Identification of Let-7f-5p as a novel biomarker of recurrence in non-muscle invasive bladder cancer. (PMID:32623385)
• let7f5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6. (PMID:33300070)
• Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway. (PMID:33710445)
• Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation. (PMID:35082326)
• Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. (PMID:35238350)
• Hsa-let-7f-1-3p targeting the circadian gene Bmal1 mediates intervertebral disc degeneration by regulating autophagy. (PMID:36334875)
• Genetic polymorphisms of pri-let-7f, gene-environment and gene-gene interactions, and associations with ischemic stroke risk in Liaoning Province. (PMID:37170751)

Cross-species orthologs

0 orthologs

Paralogs (10): MIRLET7E (ENSG00000198972), MIRLET7A2 (ENSG00000198975), MIRLET7C (ENSG00000199030), MIRLET7D (ENSG00000199133), MIRLET7G (ENSG00000199150), MIRLET7A1 (ENSG00000199165), MIRLET7I (ENSG00000199179), MIRLET7F2 (ENSG00000208012), MIR98 (ENSG00000271886), MIRLET7A3 (ENSG00000283990)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.