MIRLET7F2

Summary

MIRLET7F2 (microRNA let-7f-2, HGNC:31484) is a microRNA gene on chromosome Xp11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406889 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31484
Approved symbol	MIRLET7F2
Name	microRNA let-7f-2
Location	Xp11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-let-7f-2
Ensembl gene	ENSG00000208012
Ensembl biotype	miRNA
OMIM	300721
Entrez	406889
RNAcentral	URS000075D19A — miRNA, 83 nt, 92 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385277

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385277 — 1 exons

Exon	Start	End
ENSE00001500283	53557192	53557274

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 82.69.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	82.69	gold quality
heart	UBERON:0000948	82.39	gold quality
blood	UBERON:0000178	79.17	gold quality
stomach	UBERON:0000945	74.94	gold quality
lung	UBERON:0002048	72.49	gold quality
endometrium	UBERON:0001295	71.23	gold quality
intestine	UBERON:0000160	70.47	gold quality
right lobe of liver	UBERON:0001114	70.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.32	gold quality
upper lobe of left lung	UBERON:0008952	67.31	gold quality
body of stomach	UBERON:0001161	66.98	gold quality
left adrenal gland	UBERON:0001234	66.89	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.89	gold quality
omental fat pad	UBERON:0010414	66.63	gold quality
ascending aorta	UBERON:0001496	66.20	gold quality
transverse colon	UBERON:0001157	65.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.67	gold quality
skin of abdomen	UBERON:0001416	64.52	gold quality
cerebellar hemisphere	UBERON:0002245	64.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.08	gold quality
right ovary	UBERON:0002118	63.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.43	gold quality
substantia nigra	UBERON:0002038	61.53	gold quality
skin of leg	UBERON:0001511	61.46	gold quality
tibial artery	UBERON:0007610	60.68	gold quality
spleen	UBERON:0002106	60.57	gold quality
corpus callosum	UBERON:0002336	56.14	gold quality
thyroid gland	UBERON:0002046	55.99	gold quality
pituitary gland	UBERON:0000007	55.44	gold quality
right testis	UBERON:0004534	37.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Data show that Let-7f blocks IL-23R expression through its complementary target sequence within 3’ untranslated region of target gene. (PMID:21508257)
• miR-205 and let-7f are biomarkers for ovarian cancer and may be predictive of ovarian cancer prognosis. (PMID:24223734)
• Study show that Let-7f is down-regulated in glioma tissue and cell lines; its enhanced expression suppresses glioma cells proliferation, migration, and invasion via direct targeting perisotin suggesting it as an important role in glioma pathogenesis. (PMID:25735962)
• The combination of serum let-7b, 7d, and 7f levels during the proliferative phase may serve as a diagnostic marker for endometriosis. (PMID:25772772)
• genetic association study in population in Beijing, China: Data suggest SNPs in mirnlet7 (rs10993081 mirnlet7d, rs10877887 mirnlet7i, rs17276588 mirnlet7f) on chromosomes 9, 12, x are associated with metabolic syndrome in population studied. (PMID:26178671)
• let-7f-5p functions as a potential inhibitor of Th17 differentiation in the pathogenesis of multiple sclerosis by targeting STAT3 (PMID:31326963)
• Downregulation of microRNA let-7f mediated the Adriamycin resistance in leukemia cell line. (PMID:31793054)
• Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway. (PMID:32305960)
• Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation. (PMID:35082326)
• Genetic polymorphisms of pri-let-7f, gene-environment and gene-gene interactions, and associations with ischemic stroke risk in Liaoning Province. (PMID:37170751)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mirlet7g-1	ENSDARG00000083280
danio_rerio	mirlet7g-2	ENSDARG00000083425
mus_musculus	Mirlet7f-2	ENSMUSG00000065602
rattus_norvegicus	Mirlet7f2	ENSRNOG00000035464

Paralogs (10): MIRLET7E (ENSG00000198972), MIRLET7A2 (ENSG00000198975), MIRLET7C (ENSG00000199030), MIRLET7F1 (ENSG00000199072), MIRLET7D (ENSG00000199133), MIRLET7G (ENSG00000199150), MIRLET7A1 (ENSG00000199165), MIRLET7I (ENSG00000199179), MIR98 (ENSG00000271886), MIRLET7A3 (ENSG00000283990)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.