MITA1

Summary

MITA1 (metabolism induced tumor activator 1, HGNC:56733) is a long non-coding RNA gene on chromosome 8q21.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56733
Approved symbol	MITA1
Name	metabolism induced tumor activator 1
Location	8q21.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	IL7AS, hNAIL
Ensembl gene	ENSG00000285744
Ensembl biotype	lncRNA
Entrez	105375914
RNAcentral	URS0002A5E985 — lncRNA, 3035 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000649603

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000649603 — 6 exons

Exon	Start	End
ENSE00003831367	78938481	78940029
ENSE00003831425	78933743	78933893
ENSE00003832738	78937592	78937709
ENSE00003832943	78955502	78956082
ENSE00003837917	78942953	78943071
ENSE00004271365	78805179	78805695

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 74.41.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.41	gold quality
colonic epithelium	UBERON:0000397	69.91	silver quality
tonsil	UBERON:0002372	69.89	gold quality
liver	UBERON:0002107	68.99	gold quality
right lobe of liver	UBERON:0001114	68.43	gold quality
lymph node	UBERON:0000029	67.23	gold quality
skeletal muscle tissue	UBERON:0001134	66.93	silver quality
vermiform appendix	UBERON:0001154	64.97	gold quality
quadriceps femoris	UBERON:0001377	64.14	gold quality
islet of Langerhans	UBERON:0000006	63.68	gold quality
thymus	UBERON:0002370	63.12	silver quality
cerebellar vermis	UBERON:0004720	63.05	gold quality
right uterine tube	UBERON:0001302	62.13	gold quality
gall bladder	UBERON:0002110	61.97	gold quality
duodenum	UBERON:0002114	61.89	gold quality
rectum	UBERON:0001052	60.13	gold quality
urinary bladder	UBERON:0001255	57.24	gold quality
fallopian tube	UBERON:0003889	57.16	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	56.91	gold quality
esophagus mucosa	UBERON:0002469	56.68	gold quality
pancreas	UBERON:0001264	56.67	gold quality
adult mammalian kidney	UBERON:0000082	56.58	gold quality
kidney	UBERON:0002113	56.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.25	gold quality
lung	UBERON:0002048	56.11	gold quality
muscle tissue	UBERON:0002385	55.88	gold quality
upper lobe of left lung	UBERON:0008952	55.70	gold quality
small intestine	UBERON:0002108	55.62	gold quality
mucosa of transverse colon	UBERON:0004991	55.54	gold quality
stromal cell of endometrium	CL:0002255	55.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• High LOC105375913 expression is associated with tubulointerstitial fibrosis in focal segmental glomerulosclerosis. (PMID:30679767)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.